Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer.
Acute kidney injury (AKI) is common after gastric surgery for gastric cancer and associated with adverse outcomes. However, the impact of transient or persistent AKI on clinical outcomes after gastric surgery for gastric cancer has not been described. We performed a retrospective study of 4,886 pati...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5148089?pdf=render |
| _version_ | 1818966295363715072 |
|---|---|
| author | Chang Seong Kim Eun Hui Bae Seong Kwon Ma Sun-Seog Kweon Soo Wan Kim |
| author_facet | Chang Seong Kim Eun Hui Bae Seong Kwon Ma Sun-Seog Kweon Soo Wan Kim |
| author_sort | Chang Seong Kim |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is common after gastric surgery for gastric cancer and associated with adverse outcomes. However, the impact of transient or persistent AKI on clinical outcomes after gastric surgery for gastric cancer has not been described. We performed a retrospective study of 4,886 patients with normal renal function who underwent partial or total gastrectomy for gastric cancer between June 2002 and December 2012. AKI patients were classified as transient and persistent AKI based on the return of serum creatinine to the level indicating no AKI within 7 days. Our outcomes included occurrence of new-onset chronic kidney disease (CKD) and mortality 1 year after gastric surgery. AKI occurred in 638 (13.1%) after gastric surgery. Transient AKI was documented in 574 (90%). Use of diuretics and contrast agents was a common risk factor for persistent and transient AKI. Length of intensive care unit (ICU) and hospital stay, and ICU admission rate were higher in patients with transient AKI than in those without AKI. Although patients with persistent AKI had a higher new-onset CKD 1 year after gastric surgery after adjusting for multiple covariates, transient AKI was not associated with new-onset CKD. The 1-year mortality rates were significantly higher in patients with transient and persistent AKI. Not only persistent AKI but transient AKI is associated with increased risk of hospital complications and a significantly higher risk of long-term mortality than patients without AKI after gastric surgery. Moreover, persistent AKI, but not transient AKI, is associated with CKD progression at 1 year. |
| first_indexed | 2024-12-20T13:30:38Z |
| format | Article |
| id | doaj.art-95893022027441ab96c988969814b34e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T13:30:38Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-95893022027441ab96c988969814b34e2022-12-21T19:39:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016811910.1371/journal.pone.0168119Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer.Chang Seong KimEun Hui BaeSeong Kwon MaSun-Seog KweonSoo Wan KimAcute kidney injury (AKI) is common after gastric surgery for gastric cancer and associated with adverse outcomes. However, the impact of transient or persistent AKI on clinical outcomes after gastric surgery for gastric cancer has not been described. We performed a retrospective study of 4,886 patients with normal renal function who underwent partial or total gastrectomy for gastric cancer between June 2002 and December 2012. AKI patients were classified as transient and persistent AKI based on the return of serum creatinine to the level indicating no AKI within 7 days. Our outcomes included occurrence of new-onset chronic kidney disease (CKD) and mortality 1 year after gastric surgery. AKI occurred in 638 (13.1%) after gastric surgery. Transient AKI was documented in 574 (90%). Use of diuretics and contrast agents was a common risk factor for persistent and transient AKI. Length of intensive care unit (ICU) and hospital stay, and ICU admission rate were higher in patients with transient AKI than in those without AKI. Although patients with persistent AKI had a higher new-onset CKD 1 year after gastric surgery after adjusting for multiple covariates, transient AKI was not associated with new-onset CKD. The 1-year mortality rates were significantly higher in patients with transient and persistent AKI. Not only persistent AKI but transient AKI is associated with increased risk of hospital complications and a significantly higher risk of long-term mortality than patients without AKI after gastric surgery. Moreover, persistent AKI, but not transient AKI, is associated with CKD progression at 1 year.http://europepmc.org/articles/PMC5148089?pdf=render |
| spellingShingle | Chang Seong Kim Eun Hui Bae Seong Kwon Ma Sun-Seog Kweon Soo Wan Kim Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. PLoS ONE |
| title | Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. |
| title_full | Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. |
| title_fullStr | Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. |
| title_full_unstemmed | Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. |
| title_short | Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer. |
| title_sort | impact of transient and persistent acute kidney injury on chronic kidney disease progression and mortality after gastric surgery for gastric cancer |
| url | http://europepmc.org/articles/PMC5148089?pdf=render |
| work_keys_str_mv | AT changseongkim impactoftransientandpersistentacutekidneyinjuryonchronickidneydiseaseprogressionandmortalityaftergastricsurgeryforgastriccancer AT eunhuibae impactoftransientandpersistentacutekidneyinjuryonchronickidneydiseaseprogressionandmortalityaftergastricsurgeryforgastriccancer AT seongkwonma impactoftransientandpersistentacutekidneyinjuryonchronickidneydiseaseprogressionandmortalityaftergastricsurgeryforgastriccancer AT sunseogkweon impactoftransientandpersistentacutekidneyinjuryonchronickidneydiseaseprogressionandmortalityaftergastricsurgeryforgastriccancer AT soowankim impactoftransientandpersistentacutekidneyinjuryonchronickidneydiseaseprogressionandmortalityaftergastricsurgeryforgastriccancer |