Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support.
BACKGROUND:The mortality rate of patients on extracorporeal membrane oxygenation (ECMO), especially those patients that develop acute kidney injury (AKI) is high. Acute kidney disease (AKD) is a term used to describe the continuum from AKI to chronic kidney disease. However, the role of AKD in predi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0231505 |
| _version_ | 1818587873086013440 |
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| author | Cheng-Kai Hsu I-Wen Wu Yih-Ting Chen Tsung-Yu Tsai Feng-Chun Tsai Ji-Tseng Fang Yung-Chang Chen |
| author_facet | Cheng-Kai Hsu I-Wen Wu Yih-Ting Chen Tsung-Yu Tsai Feng-Chun Tsai Ji-Tseng Fang Yung-Chang Chen |
| author_sort | Cheng-Kai Hsu |
| collection | DOAJ |
| description | BACKGROUND:The mortality rate of patients on extracorporeal membrane oxygenation (ECMO), especially those patients that develop acute kidney injury (AKI) is high. Acute kidney disease (AKD) is a term used to describe the continuum from AKI to chronic kidney disease. However, the role of AKD in predicting the prognosis of patients on ECMO support is unclear. METHODS:A total of 168 patients who received ECMO support and survived for more than 7 days at a single hospital from 2003 to 2008 were enrolled for this study and followed up for 10 years or till mortality. Kaplan-Meier analysis and Cox proportional hazards model were used to determine the prognostic factors associated with survival. RESULTS:The median survival times of patients with stage 0, stage 1, stage 2 and stage 3 AKD were ≥ 10 years, 43.9 months, 1 month, and half a month, respectively. There were statistically significant differences in cumulative survival rate between patients with stage 3 AKD and those with stage 0, 1, and 2 AKD (Cox-Mantel log rank test, p<0.001, p<0.001, p = 0.023), and between patients with stage 0 AKD and those with stage 1 and 2 AKD (Cox-Mantel log rank test, p = 0.012, p<0.001). Cox regression analysis revealed that AKD stage (hazard ratio [HR]: 2.576, 95% confidential interval [CI]: 1.268-5.234, p = 0.009 for stage 1; HR: 2.349; 95% CI: 1.101-5.512, p = 0.029 for stage 2; HR: 5.252; 95% CI: 2.715-10.163, p<0.001 for stage 3) was significant independent predictor of survival. CONCLUSION:AKD stage is an independent predictor of survival in patients on ECMO support. |
| first_indexed | 2024-12-16T09:15:46Z |
| format | Article |
| id | doaj.art-95894917dcf24edb8fecf3a5f498360f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T09:15:46Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-95894917dcf24edb8fecf3a5f498360f2022-12-21T22:36:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023150510.1371/journal.pone.0231505Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support.Cheng-Kai HsuI-Wen WuYih-Ting ChenTsung-Yu TsaiFeng-Chun TsaiJi-Tseng FangYung-Chang ChenBACKGROUND:The mortality rate of patients on extracorporeal membrane oxygenation (ECMO), especially those patients that develop acute kidney injury (AKI) is high. Acute kidney disease (AKD) is a term used to describe the continuum from AKI to chronic kidney disease. However, the role of AKD in predicting the prognosis of patients on ECMO support is unclear. METHODS:A total of 168 patients who received ECMO support and survived for more than 7 days at a single hospital from 2003 to 2008 were enrolled for this study and followed up for 10 years or till mortality. Kaplan-Meier analysis and Cox proportional hazards model were used to determine the prognostic factors associated with survival. RESULTS:The median survival times of patients with stage 0, stage 1, stage 2 and stage 3 AKD were ≥ 10 years, 43.9 months, 1 month, and half a month, respectively. There were statistically significant differences in cumulative survival rate between patients with stage 3 AKD and those with stage 0, 1, and 2 AKD (Cox-Mantel log rank test, p<0.001, p<0.001, p = 0.023), and between patients with stage 0 AKD and those with stage 1 and 2 AKD (Cox-Mantel log rank test, p = 0.012, p<0.001). Cox regression analysis revealed that AKD stage (hazard ratio [HR]: 2.576, 95% confidential interval [CI]: 1.268-5.234, p = 0.009 for stage 1; HR: 2.349; 95% CI: 1.101-5.512, p = 0.029 for stage 2; HR: 5.252; 95% CI: 2.715-10.163, p<0.001 for stage 3) was significant independent predictor of survival. CONCLUSION:AKD stage is an independent predictor of survival in patients on ECMO support.https://doi.org/10.1371/journal.pone.0231505 |
| spellingShingle | Cheng-Kai Hsu I-Wen Wu Yih-Ting Chen Tsung-Yu Tsai Feng-Chun Tsai Ji-Tseng Fang Yung-Chang Chen Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. PLoS ONE |
| title | Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. |
| title_full | Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. |
| title_fullStr | Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. |
| title_full_unstemmed | Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. |
| title_short | Acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support. |
| title_sort | acute kidney disease stage predicts outcome of patients on extracorporeal membrane oxygenation support |
| url | https://doi.org/10.1371/journal.pone.0231505 |
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