Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction
Engineering microenvironments for accelerated myocardial repair is a challenging goal. Cell therapy has evolved over a few decades to engraft therapeutic cells to replenish lost cardiomyocytes in the left ventricle. However, compelling evidence supports that tailoring specific signals to endogenous...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.611936/full |
| _version_ | 1818962720249085952 |
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| author | Hamid Esmaeili Chaoyang Li Xing Fu Jangwook P. Jung |
| author_facet | Hamid Esmaeili Chaoyang Li Xing Fu Jangwook P. Jung |
| author_sort | Hamid Esmaeili |
| collection | DOAJ |
| description | Engineering microenvironments for accelerated myocardial repair is a challenging goal. Cell therapy has evolved over a few decades to engraft therapeutic cells to replenish lost cardiomyocytes in the left ventricle. However, compelling evidence supports that tailoring specific signals to endogenous cells rather than the direct integration of therapeutic cells could be an attractive strategy for better clinical outcomes. Of many possible routes to instruct endogenous cells, we reviewed recent cases that extracellular matrix (ECM) proteins contribute to enhanced cardiomyocyte proliferation from neonates to adults. In addition, the presence of ECM proteins exerts biophysical regulation in tissue, leading to the control of microenvironments and adaptation for enhanced cardiomyocyte proliferation. Finally, we also summarized recent clinical trials exclusively using ECM proteins, further supporting the notion that engineering ECM proteins would be a critical strategy to enhance myocardial repair without taking any risks or complications of applying therapeutic cardiac cells. |
| first_indexed | 2024-12-20T12:33:48Z |
| format | Article |
| id | doaj.art-958b1091b87b4d1e9725504912293543 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-20T12:33:48Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-958b1091b87b4d1e97255049122935432022-12-21T19:40:40ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-01-01810.3389/fbioe.2020.611936611936Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial InfarctionHamid Esmaeili0Chaoyang Li1Xing Fu2Jangwook P. Jung3Department of Biological Engineering, Louisiana State University, Baton Rouge, LA, United StatesSchool of Animal Sciences, Louisiana State University AgCenter, Baton Rouge, LA, United StatesSchool of Animal Sciences, Louisiana State University AgCenter, Baton Rouge, LA, United StatesDepartment of Biological Engineering, Louisiana State University, Baton Rouge, LA, United StatesEngineering microenvironments for accelerated myocardial repair is a challenging goal. Cell therapy has evolved over a few decades to engraft therapeutic cells to replenish lost cardiomyocytes in the left ventricle. However, compelling evidence supports that tailoring specific signals to endogenous cells rather than the direct integration of therapeutic cells could be an attractive strategy for better clinical outcomes. Of many possible routes to instruct endogenous cells, we reviewed recent cases that extracellular matrix (ECM) proteins contribute to enhanced cardiomyocyte proliferation from neonates to adults. In addition, the presence of ECM proteins exerts biophysical regulation in tissue, leading to the control of microenvironments and adaptation for enhanced cardiomyocyte proliferation. Finally, we also summarized recent clinical trials exclusively using ECM proteins, further supporting the notion that engineering ECM proteins would be a critical strategy to enhance myocardial repair without taking any risks or complications of applying therapeutic cardiac cells.https://www.frontiersin.org/articles/10.3389/fbioe.2020.611936/fullextracellular matrixcardiomyocyte proliferationmyocardial infarctioncardiac repairacellular therapeutics |
| spellingShingle | Hamid Esmaeili Chaoyang Li Xing Fu Jangwook P. Jung Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction Frontiers in Bioengineering and Biotechnology extracellular matrix cardiomyocyte proliferation myocardial infarction cardiac repair acellular therapeutics |
| title | Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction |
| title_full | Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction |
| title_fullStr | Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction |
| title_full_unstemmed | Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction |
| title_short | Engineering Extracellular Matrix Proteins to Enhance Cardiac Regeneration After Myocardial Infarction |
| title_sort | engineering extracellular matrix proteins to enhance cardiac regeneration after myocardial infarction |
| topic | extracellular matrix cardiomyocyte proliferation myocardial infarction cardiac repair acellular therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.611936/full |
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