A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT)
Background: Knee osteoarthritis (KOA) is a common public health disease with an increasing prevalence. It is one of the leading causes of disability, especially in the elderly. Intra-articular hypertonic dextrose prolotherapy is one of the therapies used for KOA. There have been some articles indica...
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| Format: | Article |
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Shiraz University of Medical Sciences
2022-06-01
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| Series: | Journal of Rehabilitation Sciences and Research |
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| Online Access: | https://jrsr.sums.ac.ir/article_48070_24a94b692900c14b028101ec7adfcbc8.pdf |
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| author | Zahra Babaeian Hamidreza Farpour Ebrahim Mostaghni Attiye Vasaghi aref nasiri Hossein Arjmand |
| author_facet | Zahra Babaeian Hamidreza Farpour Ebrahim Mostaghni Attiye Vasaghi aref nasiri Hossein Arjmand |
| author_sort | Zahra Babaeian |
| collection | DOAJ |
| description | Background: Knee osteoarthritis (KOA) is a common public health disease with an increasing prevalence. It is one of the leading causes of disability, especially in the elderly. Intra-articular hypertonic dextrose prolotherapy is one of the therapies used for KOA. There have been some articles indicating that patients receiving intra-articular normal saline as a control group of the article had improvement as well. The aim of this randomized clinical trial study was to evaluate the efficacy of intra-articular hypertonic saline in comparison with hypertonic dextrose prolotherapy in treatment of KOA.Methods: A total of 54 patients with KOA were randomized in two groups: hypertonic dextrose (28 patients) and hypertonic saline groups (26 patients). All patients received three intra-articular injections of either hypertonic dextrose or hypertonic saline at two weeks intervals. The values obtained by visual analogue pain scale (VAS), Oxford knee scale (OKS), and Western Ontario McMaster University Osteoarthritis Index (WOMAC) questionnaire were the outcome measures which were evaluated before, as well as 2 and 4 weeks after the injections. The data were analyzed using t-test and repeated measurement tests.Results: Both groups revealed improvements in outcome measures after 2 and 4 weeks of intervention. However, no statistically significant difference was found between the two groups.Conclusion: We concluded that the intra-articular injection of hypertonic dextrose and hypertonic saline are both effective in the management of KOA. Hypertonic saline can be considered as another medical agent in management of KOA. However, further studies are suggested to evaluate its long-term effects. |
| first_indexed | 2024-12-10T22:58:32Z |
| format | Article |
| id | doaj.art-958e5ff04eb6456593102b94509c10bc |
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| issn | 2345-6167 2345-6159 |
| language | English |
| last_indexed | 2024-12-10T22:58:32Z |
| publishDate | 2022-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Rehabilitation Sciences and Research |
| spelling | doaj.art-958e5ff04eb6456593102b94509c10bc2022-12-22T01:30:11ZengShiraz University of Medical SciencesJournal of Rehabilitation Sciences and Research2345-61672345-61592022-06-0192606410.30476/jrsr.2022.90605.115048070A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT)Zahra Babaeian0Hamidreza Farpour1Ebrahim Mostaghni2Attiye Vasaghi3aref nasiri4Hossein Arjmand5Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Bone and Joint Diseases Research Center, department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.Background: Knee osteoarthritis (KOA) is a common public health disease with an increasing prevalence. It is one of the leading causes of disability, especially in the elderly. Intra-articular hypertonic dextrose prolotherapy is one of the therapies used for KOA. There have been some articles indicating that patients receiving intra-articular normal saline as a control group of the article had improvement as well. The aim of this randomized clinical trial study was to evaluate the efficacy of intra-articular hypertonic saline in comparison with hypertonic dextrose prolotherapy in treatment of KOA.Methods: A total of 54 patients with KOA were randomized in two groups: hypertonic dextrose (28 patients) and hypertonic saline groups (26 patients). All patients received three intra-articular injections of either hypertonic dextrose or hypertonic saline at two weeks intervals. The values obtained by visual analogue pain scale (VAS), Oxford knee scale (OKS), and Western Ontario McMaster University Osteoarthritis Index (WOMAC) questionnaire were the outcome measures which were evaluated before, as well as 2 and 4 weeks after the injections. The data were analyzed using t-test and repeated measurement tests.Results: Both groups revealed improvements in outcome measures after 2 and 4 weeks of intervention. However, no statistically significant difference was found between the two groups.Conclusion: We concluded that the intra-articular injection of hypertonic dextrose and hypertonic saline are both effective in the management of KOA. Hypertonic saline can be considered as another medical agent in management of KOA. However, further studies are suggested to evaluate its long-term effects.https://jrsr.sums.ac.ir/article_48070_24a94b692900c14b028101ec7adfcbc8.pdfdextrosehypertonic saline solutionintra-articular injectionknee osteoarthritis |
| spellingShingle | Zahra Babaeian Hamidreza Farpour Ebrahim Mostaghni Attiye Vasaghi aref nasiri Hossein Arjmand A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) Journal of Rehabilitation Sciences and Research dextrose hypertonic saline solution intra-articular injection knee osteoarthritis |
| title | A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) |
| title_full | A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) |
| title_fullStr | A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) |
| title_full_unstemmed | A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) |
| title_short | A Comparative Study of Short-Term Efficacy of Intra-articular Hypertonic Saline and Hypertonic Dextrose Prolotherapy in Knee Osteoarthritis: A randomized controlled trial (RCT) |
| title_sort | comparative study of short term efficacy of intra articular hypertonic saline and hypertonic dextrose prolotherapy in knee osteoarthritis a randomized controlled trial rct |
| topic | dextrose hypertonic saline solution intra-articular injection knee osteoarthritis |
| url | https://jrsr.sums.ac.ir/article_48070_24a94b692900c14b028101ec7adfcbc8.pdf |
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