Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI
Convergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.533428/full |
| _version_ | 1818433521453105152 |
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| author | Ting Yang Bangli Shen Aiqin Wu Xinglu Tang Wei Chen Zhenzhong Zhang Bo Chen Zhongwei Guo Xiaozheng Liu |
| author_facet | Ting Yang Bangli Shen Aiqin Wu Xinglu Tang Wei Chen Zhenzhong Zhang Bo Chen Zhongwei Guo Xiaozheng Liu |
| author_sort | Ting Yang |
| collection | DOAJ |
| description | Convergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI) with and without depression are not clear. The current study examined the features of amygdala FC in patients with MCI with depression symptoms (D-MCI) using resting-state functional magnetic resonance imaging. We acquired resting-state functional magnetic resonance imaging data from 16 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 20 healthy controls (HCs) using a 3T scanner and compared the strength of amygdala FC between the three groups. Patients with D-MCI exhibited significant FC differences in the amygdala–medial prefrontal cortex and amygdala–sensorimotor networks. These results suggest that the dysfunction of the amygdala–medial prefrontal cortex network and the amygdala–sensorimotor network might be involved in the neural mechanism underlying depression in MCI. |
| first_indexed | 2024-12-14T16:22:25Z |
| format | Article |
| id | doaj.art-958edf062aba4fd8a69068ebc43db80b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-14T16:22:25Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-958edf062aba4fd8a69068ebc43db80b2022-12-21T22:54:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.533428533428Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRITing Yang0Bangli Shen1Aiqin Wu2Xinglu Tang3Wei Chen4Zhenzhong Zhang5Bo Chen6Zhongwei Guo7Xiaozheng Liu8The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaTongde Hospital of Zhejiang, Hangzhou, ChinaTongde Hospital of Zhejiang, Hangzhou, ChinaTongde Hospital of Zhejiang, Hangzhou, ChinaThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, ChinaConvergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI) with and without depression are not clear. The current study examined the features of amygdala FC in patients with MCI with depression symptoms (D-MCI) using resting-state functional magnetic resonance imaging. We acquired resting-state functional magnetic resonance imaging data from 16 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 20 healthy controls (HCs) using a 3T scanner and compared the strength of amygdala FC between the three groups. Patients with D-MCI exhibited significant FC differences in the amygdala–medial prefrontal cortex and amygdala–sensorimotor networks. These results suggest that the dysfunction of the amygdala–medial prefrontal cortex network and the amygdala–sensorimotor network might be involved in the neural mechanism underlying depression in MCI.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.533428/fullmild cognitive impairmentdepressionfunctional magnetic resonance imagingfunctional connectivityamygdala |
| spellingShingle | Ting Yang Bangli Shen Aiqin Wu Xinglu Tang Wei Chen Zhenzhong Zhang Bo Chen Zhongwei Guo Xiaozheng Liu Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI Frontiers in Psychiatry mild cognitive impairment depression functional magnetic resonance imaging functional connectivity amygdala |
| title | Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI |
| title_full | Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI |
| title_fullStr | Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI |
| title_full_unstemmed | Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI |
| title_short | Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI |
| title_sort | abnormal functional connectivity of the amygdala in mild cognitive impairment patients with depression symptoms revealed by resting state fmri |
| topic | mild cognitive impairment depression functional magnetic resonance imaging functional connectivity amygdala |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.533428/full |
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