Complex Physical Properties of an Adaptive, Self-Organizing Biological System
Physical modeling of the functioning of the adaptive immune system, which has been thoroughly characterized on genetic and molecular levels, provides a unique opportunity to define an adaptive, self-organizing biological system in its entirety. This paper describes a configuration space model of imm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biophysica |
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| Online Access: | https://www.mdpi.com/2673-4125/3/2/15 |
| _version_ | 1827738264171184128 |
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| author | József Prechl |
| author_facet | József Prechl |
| author_sort | József Prechl |
| collection | DOAJ |
| description | Physical modeling of the functioning of the adaptive immune system, which has been thoroughly characterized on genetic and molecular levels, provides a unique opportunity to define an adaptive, self-organizing biological system in its entirety. This paper describes a configuration space model of immune function, where directed chemical potentials of the system constitute a space of interactions. A mathematical approach is used to define the system that couples the variance of Gaussian distributed interaction energies in its interaction space to the exponentially distributed chemical potentials of its effector molecules to maintain its steady state. The model is validated by identifying the thermodynamic and network variables analogous to the mathematical parameters and by applying the model to the humoral immune system. Overall, this statistical thermodynamics model of adaptive immunity describes how adaptive biological self-organization arises from the maintenance of a scale-free, directed molecular interaction network with fractal topology. |
| first_indexed | 2024-03-11T02:41:57Z |
| format | Article |
| id | doaj.art-958fb1fa7e864bcaaf7978b4479fe445 |
| institution | Directory Open Access Journal |
| issn | 2673-4125 |
| language | English |
| last_indexed | 2024-03-11T02:41:57Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biophysica |
| spelling | doaj.art-958fb1fa7e864bcaaf7978b4479fe4452023-11-18T09:31:59ZengMDPI AGBiophysica2673-41252023-03-013223125110.3390/biophysica3020015Complex Physical Properties of an Adaptive, Self-Organizing Biological SystemJózsef Prechl0R&D Laboratory, Diagnosticum Zrt., H-1047 Budapest, HungaryPhysical modeling of the functioning of the adaptive immune system, which has been thoroughly characterized on genetic and molecular levels, provides a unique opportunity to define an adaptive, self-organizing biological system in its entirety. This paper describes a configuration space model of immune function, where directed chemical potentials of the system constitute a space of interactions. A mathematical approach is used to define the system that couples the variance of Gaussian distributed interaction energies in its interaction space to the exponentially distributed chemical potentials of its effector molecules to maintain its steady state. The model is validated by identifying the thermodynamic and network variables analogous to the mathematical parameters and by applying the model to the humoral immune system. Overall, this statistical thermodynamics model of adaptive immunity describes how adaptive biological self-organization arises from the maintenance of a scale-free, directed molecular interaction network with fractal topology.https://www.mdpi.com/2673-4125/3/2/15systemnetworkchemical potentialthermodynamic activityantibodyself-organization |
| spellingShingle | József Prechl Complex Physical Properties of an Adaptive, Self-Organizing Biological System Biophysica system network chemical potential thermodynamic activity antibody self-organization |
| title | Complex Physical Properties of an Adaptive, Self-Organizing Biological System |
| title_full | Complex Physical Properties of an Adaptive, Self-Organizing Biological System |
| title_fullStr | Complex Physical Properties of an Adaptive, Self-Organizing Biological System |
| title_full_unstemmed | Complex Physical Properties of an Adaptive, Self-Organizing Biological System |
| title_short | Complex Physical Properties of an Adaptive, Self-Organizing Biological System |
| title_sort | complex physical properties of an adaptive self organizing biological system |
| topic | system network chemical potential thermodynamic activity antibody self-organization |
| url | https://www.mdpi.com/2673-4125/3/2/15 |
| work_keys_str_mv | AT jozsefprechl complexphysicalpropertiesofanadaptiveselforganizingbiologicalsystem |