Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation

Objective: Hypothyroidism is known as the most common endocrine disorder. The prevalence of hypothyroidism in the female and male population is 2% and 0.2%, respectively. Maternal hypothyroidism is a defect in the thyroid hormones transition from the mother to the fetus. The present study was cond...

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Main Authors: Faezeh Panahandeh, Farideh Feizi, Mohsen Pourghasem, Sorya Khafri, Zeinab Abedian, Kaveh Pourghasem, Zohre Esmaeili
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2022-03-01
Series:Cell Journal
Subjects:
Online Access:https://celljournal.org/journal/article/fulltext/study-of-the-effect-of-hyperthyroidism-on-the-male-and-female-fertility-and-histological-changes-of-the-gonads-in-second-generation-rats-an-experimental-study.pdf
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author Faezeh Panahandeh
Farideh Feizi
Mohsen Pourghasem
Sorya Khafri
Zeinab Abedian
Kaveh Pourghasem
Zohre Esmaeili
author_facet Faezeh Panahandeh
Farideh Feizi
Mohsen Pourghasem
Sorya Khafri
Zeinab Abedian
Kaveh Pourghasem
Zohre Esmaeili
author_sort Faezeh Panahandeh
collection DOAJ
description Objective: Hypothyroidism is known as the most common endocrine disorder. The prevalence of hypothyroidism in the female and male population is 2% and 0.2%, respectively. Maternal hypothyroidism is a defect in the thyroid hormones transition from the mother to the fetus. The present study was conducted to find whether maternal hypothyroidism affects the fertility of the second generation. Materials and Methods: In this experimental study, twelve adult female rats weighting 180-220 g were randomly divided into case and control groups. Hypothyroidism was induced by dissolving 0.1 g/L of 6-n-propyl-2-thiouracil in drinking water toward the end of pregnancy and lactation. At the end of the breastfeeding period, the blood samples of female children were collected. Six healthy, mature, female rats were selected and kept until they reached maturity, and were then mated with male rats. After observing the female rats’ delivery, blood samples were collected from their male and female newborns and the healthy rats were selected. Results: There was a significant difference in the volume and size of ovarian as well as in the number of secondary follicles in comparison with the control group (P=0.025). However, there were no significant changes in the other parameters including the number of primary follicles, the number of Graafian follicles and sperm parameters. There was no significant decrease in the testicular volume and size, number of Leydig cells and seminiferous tubules diameter. Conclusion: Maternal hypothyroidism has no significant effects on testicular tissue function, and sperm parameters in the second generation, but can significantly reduce the rate of secondary follicles in the second generation female rats.
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spelling doaj.art-9590cb6d03cc4a73b61d771750e467312022-12-21T18:50:25ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142022-03-0124314815410.22074/cellj.2022.8054Hypothyroidism and Fertility: An Animal Model follows up in The Second-GenerationFaezeh Panahandeh0Farideh Feizi1Mohsen Pourghasem2Sorya Khafri3Zeinab Abedian4Kaveh Pourghasem5Zohre Esmaeili6Department of Anatomy, Embryology and Histology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranDepartment of Anatomy, Embryology and Histology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranDepartment of Anatomy, Embryology and Histology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Medical Sciences, Macquarie University, Sydney, NSW, AustraliaDepartment of Anatomy, Embryology and Histology, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranObjective: Hypothyroidism is known as the most common endocrine disorder. The prevalence of hypothyroidism in the female and male population is 2% and 0.2%, respectively. Maternal hypothyroidism is a defect in the thyroid hormones transition from the mother to the fetus. The present study was conducted to find whether maternal hypothyroidism affects the fertility of the second generation. Materials and Methods: In this experimental study, twelve adult female rats weighting 180-220 g were randomly divided into case and control groups. Hypothyroidism was induced by dissolving 0.1 g/L of 6-n-propyl-2-thiouracil in drinking water toward the end of pregnancy and lactation. At the end of the breastfeeding period, the blood samples of female children were collected. Six healthy, mature, female rats were selected and kept until they reached maturity, and were then mated with male rats. After observing the female rats’ delivery, blood samples were collected from their male and female newborns and the healthy rats were selected. Results: There was a significant difference in the volume and size of ovarian as well as in the number of secondary follicles in comparison with the control group (P=0.025). However, there were no significant changes in the other parameters including the number of primary follicles, the number of Graafian follicles and sperm parameters. There was no significant decrease in the testicular volume and size, number of Leydig cells and seminiferous tubules diameter. Conclusion: Maternal hypothyroidism has no significant effects on testicular tissue function, and sperm parameters in the second generation, but can significantly reduce the rate of secondary follicles in the second generation female rats.https://celljournal.org/journal/article/fulltext/study-of-the-effect-of-hyperthyroidism-on-the-male-and-female-fertility-and-histological-changes-of-the-gonads-in-second-generation-rats-an-experimental-study.pdfcongenital hypothyroidismfertilizationovarypropylthiouraciltestis
spellingShingle Faezeh Panahandeh
Farideh Feizi
Mohsen Pourghasem
Sorya Khafri
Zeinab Abedian
Kaveh Pourghasem
Zohre Esmaeili
Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
Cell Journal
congenital hypothyroidism
fertilization
ovary
propylthiouracil
testis
title Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
title_full Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
title_fullStr Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
title_full_unstemmed Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
title_short Hypothyroidism and Fertility: An Animal Model follows up in The Second-Generation
title_sort hypothyroidism and fertility an animal model follows up in the second generation
topic congenital hypothyroidism
fertilization
ovary
propylthiouracil
testis
url https://celljournal.org/journal/article/fulltext/study-of-the-effect-of-hyperthyroidism-on-the-male-and-female-fertility-and-histological-changes-of-the-gonads-in-second-generation-rats-an-experimental-study.pdf
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AT mohsenpourghasem hypothyroidismandfertilityananimalmodelfollowsupinthesecondgeneration
AT soryakhafri hypothyroidismandfertilityananimalmodelfollowsupinthesecondgeneration
AT zeinababedian hypothyroidismandfertilityananimalmodelfollowsupinthesecondgeneration
AT kavehpourghasem hypothyroidismandfertilityananimalmodelfollowsupinthesecondgeneration
AT zohreesmaeili hypothyroidismandfertilityananimalmodelfollowsupinthesecondgeneration