First case of bloodstream infection caused by NDM-positive Escherichia hermannii
Abstract Background Escherichia hermannii (E. hermanni) is always accompanied by other bacterial infections in humans. In previous reports, most E. hermannii-related infections were caused by sensitive strains. Here, for the first time, we report the case of a patient with New Delhi metallo-β-lactam...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08336-3 |
| _version_ | 1827940056790204416 |
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| author | Bin Lu Bin Wang Xinling Pan Chenxin Liu Chenyuan Jin Yunzhen Shi Yangxiao Zhou |
| author_facet | Bin Lu Bin Wang Xinling Pan Chenxin Liu Chenyuan Jin Yunzhen Shi Yangxiao Zhou |
| author_sort | Bin Lu |
| collection | DOAJ |
| description | Abstract Background Escherichia hermannii (E. hermanni) is always accompanied by other bacterial infections in humans. In previous reports, most E. hermannii-related infections were caused by sensitive strains. Here, for the first time, we report the case of a patient with New Delhi metallo-β-lactamase (NDM)-positive E. hermannii bloodstream infection. Case presentation The patient was a 70-year-old male admitted to our hospital due to a 4-day fever, with a history of malignant tumor, liver cirrhosis, and chronic obstructive pulmonary disease. After admission, his blood culture tested positive for E. hermannii. The drug resistance analysis showed positive for NDM resistance, with susceptibility to aztreonam, levofloxacin, and amikacin. The blood culture turned negative after 8 days of aztreonam treatment. The patient’s symptoms improved, and he was discharged after 14 days of hospitalization. Conclusions This is the first report of a bloodstream infection caused by an NDM-positive E. hermannii strain. The anti-infection regimen used in this case provides a new reference regimen for clinical practice. |
| first_indexed | 2024-03-13T09:03:48Z |
| format | Article |
| id | doaj.art-95930cd196184166a1d94bae2b51e7ec |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-13T09:03:48Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-95930cd196184166a1d94bae2b51e7ec2023-05-28T11:09:34ZengBMCBMC Infectious Diseases1471-23342023-05-012311510.1186/s12879-023-08336-3First case of bloodstream infection caused by NDM-positive Escherichia hermanniiBin Lu0Bin Wang1Xinling Pan2Chenxin Liu3Chenyuan Jin4Yunzhen Shi5Yangxiao Zhou6Department of Infectious Diseases, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Emergency, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Infectious Diseases, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Infectious Diseases, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Infectious Diseases, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical UniversityAbstract Background Escherichia hermannii (E. hermanni) is always accompanied by other bacterial infections in humans. In previous reports, most E. hermannii-related infections were caused by sensitive strains. Here, for the first time, we report the case of a patient with New Delhi metallo-β-lactamase (NDM)-positive E. hermannii bloodstream infection. Case presentation The patient was a 70-year-old male admitted to our hospital due to a 4-day fever, with a history of malignant tumor, liver cirrhosis, and chronic obstructive pulmonary disease. After admission, his blood culture tested positive for E. hermannii. The drug resistance analysis showed positive for NDM resistance, with susceptibility to aztreonam, levofloxacin, and amikacin. The blood culture turned negative after 8 days of aztreonam treatment. The patient’s symptoms improved, and he was discharged after 14 days of hospitalization. Conclusions This is the first report of a bloodstream infection caused by an NDM-positive E. hermannii strain. The anti-infection regimen used in this case provides a new reference regimen for clinical practice.https://doi.org/10.1186/s12879-023-08336-3Escherichia hermanniiNDM-positiveBloodstream infectionAztreonam |
| spellingShingle | Bin Lu Bin Wang Xinling Pan Chenxin Liu Chenyuan Jin Yunzhen Shi Yangxiao Zhou First case of bloodstream infection caused by NDM-positive Escherichia hermannii BMC Infectious Diseases Escherichia hermannii NDM-positive Bloodstream infection Aztreonam |
| title | First case of bloodstream infection caused by NDM-positive Escherichia hermannii |
| title_full | First case of bloodstream infection caused by NDM-positive Escherichia hermannii |
| title_fullStr | First case of bloodstream infection caused by NDM-positive Escherichia hermannii |
| title_full_unstemmed | First case of bloodstream infection caused by NDM-positive Escherichia hermannii |
| title_short | First case of bloodstream infection caused by NDM-positive Escherichia hermannii |
| title_sort | first case of bloodstream infection caused by ndm positive escherichia hermannii |
| topic | Escherichia hermannii NDM-positive Bloodstream infection Aztreonam |
| url | https://doi.org/10.1186/s12879-023-08336-3 |
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