THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN
HLA-DR locus includes immune response genes (Ir), which are controlled by thymus-dependent immune responses to endobiotiki and xenon. In pregnancy, maternal microenvironment Ir genes may determine the effectiveness of the protection of the embryo and fetus by teratogens. Accordingly, the purpose of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2016-06-01
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| Series: | Мать и дитя в Кузбассе |
| Subjects: | |
| Online Access: | http://mednauki.ru/index.php/MD/article/view/27 |
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| author | Андрей Владимирович Шабалдин Анна Викторовна Цепокина Надежда Алексеевна Литвинова Светлана Александровна Шмулевич Павел Михайлович Крюков |
| author_facet | Андрей Владимирович Шабалдин Анна Викторовна Цепокина Надежда Алексеевна Литвинова Светлана Александровна Шмулевич Павел Михайлович Крюков |
| author_sort | Андрей Владимирович Шабалдин |
| collection | DOAJ |
| description | HLA-DR locus includes immune response genes (Ir), which are controlled by thymus-dependent immune responses to endobiotiki and xenon. In pregnancy, maternal microenvironment Ir genes may determine the effectiveness of the protection of the embryo and fetus by teratogens. Accordingly, the purpose of the present study was to investigate the contribution of women of alleles and genotypes of the gene HLA-DRB1* in the risk of septal congenital heart diseases. The comparative analysis (case-control) allele frequencies and genotype HLA-DRB1* women who have children with septal congenital heart disease (experimental group, n = 97) and women with healthy children (control group, n = 54). HLA-DRB1*03 and HLA-DRB1*11 were associated with a high risk of developing CHD: HLA-DRB1*03 (OR = 5,56) and HLA-DRB1*11 (OR = 4,31). Showing and protective against this disease allele HLA-DRB1*12 (OR = 0,28) and genotype HLA-DRB1*01,12 (OR = 0,06). |
| first_indexed | 2024-04-13T00:04:55Z |
| format | Article |
| id | doaj.art-9595f09a1e2e43d4be9f4c751e980f71 |
| institution | Directory Open Access Journal |
| issn | 1991-010X 2542-0968 |
| language | Russian |
| last_indexed | 2024-04-13T00:04:55Z |
| publishDate | 2016-06-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Мать и дитя в Кузбассе |
| spelling | doaj.art-9595f09a1e2e43d4be9f4c751e980f712022-12-22T03:11:15ZrusThe Publishing House Medicine and EnlightenmentМать и дитя в Кузбассе1991-010X2542-09682016-06-01172151922THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDRENАндрей Владимирович Шабалдин0Анна Викторовна Цепокина1Надежда Алексеевна Литвинова2Светлана Александровна Шмулевич3Павел Михайлович Крюков4ФГБНУ «НИИ КПССЗ», г. КемеровоФГБНУ «НИИ КПССЗ», г. КемеровоФГБОУ ВПО «КемГУ», г. КемеровоМБУЗ «ККД», г. КемеровоМАУЗ «ДГКБ №5», г. КемеровоHLA-DR locus includes immune response genes (Ir), which are controlled by thymus-dependent immune responses to endobiotiki and xenon. In pregnancy, maternal microenvironment Ir genes may determine the effectiveness of the protection of the embryo and fetus by teratogens. Accordingly, the purpose of the present study was to investigate the contribution of women of alleles and genotypes of the gene HLA-DRB1* in the risk of septal congenital heart diseases. The comparative analysis (case-control) allele frequencies and genotype HLA-DRB1* women who have children with septal congenital heart disease (experimental group, n = 97) and women with healthy children (control group, n = 54). HLA-DRB1*03 and HLA-DRB1*11 were associated with a high risk of developing CHD: HLA-DRB1*03 (OR = 5,56) and HLA-DRB1*11 (OR = 4,31). Showing and protective against this disease allele HLA-DRB1*12 (OR = 0,28) and genotype HLA-DRB1*01,12 (OR = 0,06).http://mednauki.ru/index.php/MD/article/view/27hla-drb1*септальные врожденные пороки сердцаir гены |
| spellingShingle | Андрей Владимирович Шабалдин Анна Викторовна Цепокина Надежда Алексеевна Литвинова Светлана Александровна Шмулевич Павел Михайлович Крюков THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN Мать и дитя в Кузбассе hla-drb1* септальные врожденные пороки сердца ir гены |
| title | THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN |
| title_full | THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN |
| title_fullStr | THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN |
| title_full_unstemmed | THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN |
| title_short | THE ASSOCIATION OF MATERNAL HLA-DRB1* WITH RISK OF DEVELOPMENT CONGENITAL SEPTAL HEART DEFECTS AT THEIR CHILDREN |
| title_sort | association of maternal hla drb1 with risk of development congenital septal heart defects at their children |
| topic | hla-drb1* септальные врожденные пороки сердца ir гены |
| url | http://mednauki.ru/index.php/MD/article/view/27 |
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