AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC
To date, over 163 million confirmed cases of COVID-19 and over 3.3 million deaths from COVID-19 have been reported by the World Health Organization (WHO). However, there is still no specific treatment for the disease. Some empirical and supportive medications have been used thus far, including antiv...
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| Format: | Article |
| Language: | English |
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South Kazakhstan Medical Academy
2021-07-01
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| Series: | Central Asian Journal of Medical Hypotheses and Ethics |
| Subjects: | |
| Online Access: | https://cajmhe.com/index.php/journal/article/view/65 |
| _version_ | 1818728029777559552 |
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| author | Serkan Ergözen Egemen Kaya |
| author_facet | Serkan Ergözen Egemen Kaya |
| author_sort | Serkan Ergözen |
| collection | DOAJ |
| description | To date, over 163 million confirmed cases of COVID-19 and over 3.3 million deaths from COVID-19 have been reported by the World Health Organization (WHO). However, there is still no specific treatment for the disease. Some empirical and supportive medications have been used thus far, including antivirals, antipyretics, antibiotics, and corticosteroids. Corticosteroids are anti-inflammatory and immunosuppressive medications that are used to treat several diseases. These agents can produce undesirable and occasionally severe systemic adverse effects. Although the occurrence and severity of most adverse effects are related to the dose and duration of the corticosteroid therapy, avascular necrosis is not directly associated with this dose and duration, and may occur without osteoporosis. Corticosteroids are not recommended for routine use in COVID-19 patients by the WHO. However, these medications have been widely used for their treatment. Avascular necrosis is a progressive and incapacitating condition. The causes of avascular necrosis are categorized into traumatic and non-traumatic. The majority of non-traumatic cases are associated with the use of corticosteroids. Early diagnosis and treatment is crucial owing to the rapidly progressive nature of the disease. Severe COVID-19 patients are at risk of avascular necrosis due to corticosteroid therapy. The hypothesis presented herein suggests that hyperbaric oxygenation in combination with adequate calcium and vitamin D supplementation and individualized exercise may be an effective, safe, and noninvasive treatment modality, preventing from the progression of avascular necrosis. |
| first_indexed | 2024-12-17T22:23:30Z |
| format | Article |
| id | doaj.art-959824469c584a46a259367f7c382f0e |
| institution | Directory Open Access Journal |
| issn | 2708-9800 |
| language | English |
| last_indexed | 2024-12-17T22:23:30Z |
| publishDate | 2021-07-01 |
| publisher | South Kazakhstan Medical Academy |
| record_format | Article |
| series | Central Asian Journal of Medical Hypotheses and Ethics |
| spelling | doaj.art-959824469c584a46a259367f7c382f0e2022-12-21T21:30:25ZengSouth Kazakhstan Medical AcademyCentral Asian Journal of Medical Hypotheses and Ethics2708-98002021-07-0122919510.47316/cajmhe.2021.2.2.0365AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMICSerkan Ergözen0Egemen Kaya1Department of Underwater and Hyperbaric Medicine, Muğla Sıtkı Koçman University School of Medicine, Muğla, TurkeyDepartment of Physiology, Muğla Sıtkı Koçman University School of Medicine, Muğla, TurkeyTo date, over 163 million confirmed cases of COVID-19 and over 3.3 million deaths from COVID-19 have been reported by the World Health Organization (WHO). However, there is still no specific treatment for the disease. Some empirical and supportive medications have been used thus far, including antivirals, antipyretics, antibiotics, and corticosteroids. Corticosteroids are anti-inflammatory and immunosuppressive medications that are used to treat several diseases. These agents can produce undesirable and occasionally severe systemic adverse effects. Although the occurrence and severity of most adverse effects are related to the dose and duration of the corticosteroid therapy, avascular necrosis is not directly associated with this dose and duration, and may occur without osteoporosis. Corticosteroids are not recommended for routine use in COVID-19 patients by the WHO. However, these medications have been widely used for their treatment. Avascular necrosis is a progressive and incapacitating condition. The causes of avascular necrosis are categorized into traumatic and non-traumatic. The majority of non-traumatic cases are associated with the use of corticosteroids. Early diagnosis and treatment is crucial owing to the rapidly progressive nature of the disease. Severe COVID-19 patients are at risk of avascular necrosis due to corticosteroid therapy. The hypothesis presented herein suggests that hyperbaric oxygenation in combination with adequate calcium and vitamin D supplementation and individualized exercise may be an effective, safe, and noninvasive treatment modality, preventing from the progression of avascular necrosis.https://cajmhe.com/index.php/journal/article/view/65avascular necrosiscorticosteroidcovid-19early diagnosishyperbaric oxygenationosteonecrosistreatment |
| spellingShingle | Serkan Ergözen Egemen Kaya AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC Central Asian Journal of Medical Hypotheses and Ethics avascular necrosis corticosteroid covid-19 early diagnosis hyperbaric oxygenation osteonecrosis treatment |
| title | AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC |
| title_full | AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC |
| title_fullStr | AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC |
| title_full_unstemmed | AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC |
| title_short | AVASCULAR NECROSIS DUE TO CORTICOSTEROID THERAPY IN COVID-19 AS A SYNDEMIC |
| title_sort | avascular necrosis due to corticosteroid therapy in covid 19 as a syndemic |
| topic | avascular necrosis corticosteroid covid-19 early diagnosis hyperbaric oxygenation osteonecrosis treatment |
| url | https://cajmhe.com/index.php/journal/article/view/65 |
| work_keys_str_mv | AT serkanergozen avascularnecrosisduetocorticosteroidtherapyincovid19asasyndemic AT egemenkaya avascularnecrosisduetocorticosteroidtherapyincovid19asasyndemic |