JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient
Abstract Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML). Here, we present a rare case of PML caused by JC virus infection in a previously healthy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-03004-6 |
| _version_ | 1811179000320491520 |
|---|---|
| author | Xiang Wang Jinxiu Chen Jing Gong Ying Wu Xiang-hao Liu |
| author_facet | Xiang Wang Jinxiu Chen Jing Gong Ying Wu Xiang-hao Liu |
| author_sort | Xiang Wang |
| collection | DOAJ |
| description | Abstract Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML). Here, we present a rare case of PML caused by JC virus infection in a previously healthy and immunocompetent patient. Case presentation A 67-year-old female without any disease history was admitted after presenting with rapidly progressive dementia. The preoperative diagnosis was progressive multifocal leukoencephalopathy, and corticosteroid treatment did not improve the symptoms. Brain lesions were surgically sampled, and JCV infection was confirmed by high-throughput DNA gene detection. This patient received a combined treatment of mirtazapine, mefloquine, and traditional Chinese herbs, and had stabilization of the disease on followed-up. Conclusions Although it is a rare, this case demonstrates that JC virus infection within the brain occurs in apparently healthy people. This case may increase our understanding of virus infection when facing the coronavirus epidemic in recent years, considering that similar medications were used. Graphical Abstract |
| first_indexed | 2024-04-11T06:27:31Z |
| format | Article |
| id | doaj.art-959ca909c5f449a3b2b814fa711fec34 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-11T06:27:31Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-959ca909c5f449a3b2b814fa711fec342022-12-22T04:40:18ZengBMCBMC Neurology1471-23772022-12-012211510.1186/s12883-022-03004-6JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patientXiang Wang0Jinxiu Chen1Jing Gong2Ying Wu3Xiang-hao Liu4Department of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Radiology, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Sciences and Technology of ChinaDepartment of Pathology, West China Hospital of Sichuan UniversityDepartment of Neurology, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, West China Hospital of Sichuan UniversityAbstract Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML). Here, we present a rare case of PML caused by JC virus infection in a previously healthy and immunocompetent patient. Case presentation A 67-year-old female without any disease history was admitted after presenting with rapidly progressive dementia. The preoperative diagnosis was progressive multifocal leukoencephalopathy, and corticosteroid treatment did not improve the symptoms. Brain lesions were surgically sampled, and JCV infection was confirmed by high-throughput DNA gene detection. This patient received a combined treatment of mirtazapine, mefloquine, and traditional Chinese herbs, and had stabilization of the disease on followed-up. Conclusions Although it is a rare, this case demonstrates that JC virus infection within the brain occurs in apparently healthy people. This case may increase our understanding of virus infection when facing the coronavirus epidemic in recent years, considering that similar medications were used. Graphical Abstracthttps://doi.org/10.1186/s12883-022-03004-6Progressive multifocal leukoencephalopathyJC virusImmunocompetenceMirtazapineMefloquine |
| spellingShingle | Xiang Wang Jinxiu Chen Jing Gong Ying Wu Xiang-hao Liu JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient BMC Neurology Progressive multifocal leukoencephalopathy JC virus Immunocompetence Mirtazapine Mefloquine |
| title | JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| title_full | JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| title_fullStr | JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| title_full_unstemmed | JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| title_short | JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| title_sort | jc virus induced progressive multifocal leukoencephalopathy in a presumably healthy patient |
| topic | Progressive multifocal leukoencephalopathy JC virus Immunocompetence Mirtazapine Mefloquine |
| url | https://doi.org/10.1186/s12883-022-03004-6 |
| work_keys_str_mv | AT xiangwang jcvirusinducedprogressivemultifocalleukoencephalopathyinapresumablyhealthypatient AT jinxiuchen jcvirusinducedprogressivemultifocalleukoencephalopathyinapresumablyhealthypatient AT jinggong jcvirusinducedprogressivemultifocalleukoencephalopathyinapresumablyhealthypatient AT yingwu jcvirusinducedprogressivemultifocalleukoencephalopathyinapresumablyhealthypatient AT xianghaoliu jcvirusinducedprogressivemultifocalleukoencephalopathyinapresumablyhealthypatient |