Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation
Background: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative phy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | Integrative Medicine Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422017300847 |
| _version_ | 1819294459518517248 |
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| author | Eun Bo Shim Chae Hun Leem Joong Jae Kim Jong Yeol Kim |
| author_facet | Eun Bo Shim Chae Hun Leem Joong Jae Kim Jong Yeol Kim |
| author_sort | Eun Bo Shim |
| collection | DOAJ |
| description | Background: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative physiology to explain this phenomenon.
Methods: Hypoactive lung function in the TE type indicates that respiration is attenuated at the cellular level—specifically, mitochondrial oxygen consumption. Because a functional reduction in cellular energy metabolism is suggestive of intrinsic hypoactivity in the consumption (or production) of metabolic energy, we reasoned that this tendency can readily cause weight gain via an increase in anabolism. Thus, this relationship can be derived from the graph of cellular metabolic power plotted against body weight. We analyzed the clinical data of 548 individuals to test this hypothesis.
Results: The statistical analysis revealed that the cellular metabolic rate was lower in TE-type individuals and that their percentage of obesity (body mass index >25) was significantly higher compared to other constitutional groups.
Conclusion: Lower cellular metabolic power can be an explanation for the obesity trend in TE type people. |
| first_indexed | 2024-12-24T04:26:40Z |
| format | Article |
| id | doaj.art-959dbde7b90c4d0bbbc676c0d6fcda65 |
| institution | Directory Open Access Journal |
| issn | 2213-4220 |
| language | English |
| last_indexed | 2024-12-24T04:26:40Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj.art-959dbde7b90c4d0bbbc676c0d6fcda652022-12-21T17:15:34ZengElsevierIntegrative Medicine Research2213-42202017-09-016325425910.1016/j.imr.2017.06.006Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observationEun Bo Shim0Chae Hun Leem1Joong Jae Kim2Jong Yeol Kim3Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, KoreaDepartment of Physiology, University of Ulsan College of Medicine, Seoul, KoreaResearch Institute of Medical Devices, Kangwon National University, Chuncheon, KoreaKM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon, KoreaBackground: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative physiology to explain this phenomenon. Methods: Hypoactive lung function in the TE type indicates that respiration is attenuated at the cellular level—specifically, mitochondrial oxygen consumption. Because a functional reduction in cellular energy metabolism is suggestive of intrinsic hypoactivity in the consumption (or production) of metabolic energy, we reasoned that this tendency can readily cause weight gain via an increase in anabolism. Thus, this relationship can be derived from the graph of cellular metabolic power plotted against body weight. We analyzed the clinical data of 548 individuals to test this hypothesis. Results: The statistical analysis revealed that the cellular metabolic rate was lower in TE-type individuals and that their percentage of obesity (body mass index >25) was significantly higher compared to other constitutional groups. Conclusion: Lower cellular metabolic power can be an explanation for the obesity trend in TE type people.http://www.sciencedirect.com/science/article/pii/S2213422017300847cellular metabolic power hypothesisobesitySasang constitutional medicinescaling law of metabolic rateTae-Eum type |
| spellingShingle | Eun Bo Shim Chae Hun Leem Joong Jae Kim Jong Yeol Kim Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation Integrative Medicine Research cellular metabolic power hypothesis obesity Sasang constitutional medicine scaling law of metabolic rate Tae-Eum type |
| title | Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation |
| title_full | Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation |
| title_fullStr | Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation |
| title_full_unstemmed | Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation |
| title_short | Lower cellular metabolic power can be an explanation for obesity trend in Tae-Eum type: hypothesis and clinical observation |
| title_sort | lower cellular metabolic power can be an explanation for obesity trend in tae eum type hypothesis and clinical observation |
| topic | cellular metabolic power hypothesis obesity Sasang constitutional medicine scaling law of metabolic rate Tae-Eum type |
| url | http://www.sciencedirect.com/science/article/pii/S2213422017300847 |
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