Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.

Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.

The presence of certain MHC class I alleles is correlated with remarkable control of HIV and SIV, indicating that specific CD8 T cell responses can effectively reduce viral replication. It remains unclear whether epitopic breadth is an important feature of this control. Previous studies have suggest...

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Bibliographic Details
Main Authors: Justin M Greene, Emily N Chin, Melisa L Budde, Jennifer J Lhost, Paul J Hines, Benjamin J Burwitz, Karl W Broman, Jennifer E Nelson, Thomas C Friedrich, David H O'Connor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3425510?pdf=render

Internet

http://europepmc.org/articles/PMC3425510?pdf=render

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