A Perspective for Ménière’s Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2

A Perspective for Ménière’s Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2

Ménière’s disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the endolymph, so-called hydrops. Dexamethaso...

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Bibliographic Details
Main Authors: Robin Mom, Julien Robert-Paganin, Thierry Mom, Christian Chabbert, Stéphane Réty, Daniel Auguin
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomolecules
Subjects:
human AQP2
dexamethasone
Ménière’s disease
water channel
water permeability modulation
molecular dynamics
Online Access:https://www.mdpi.com/2218-273X/12/4/511

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