Septin-associated protein kinases in the yeast Saccharomyces cerevisiae
Septins are a family of eukaryotic GTP-binding proteins that associate into linear rods, which, in turn, polymerize end-on-end into filaments and further assemble into other, more elaborate super-structures at discrete subcellular locations. Hence, septin-based ensembles are considered elements of t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00119/full |
| _version_ | 1828285894446022656 |
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| author | Jeremy THORNER |
| author_facet | Jeremy THORNER |
| author_sort | Jeremy THORNER |
| collection | DOAJ |
| description | Septins are a family of eukaryotic GTP-binding proteins that associate into linear rods, which, in turn, polymerize end-on-end into filaments and further assemble into other, more elaborate super-structures at discrete subcellular locations. Hence, septin-based ensembles are considered elements of the cytoskeleton. One function of these structures that has been well-documented in studies conducted in budding yeast Saccharomyces cerevisiae is to serve as a scaffold that recruits regulatory proteins, which dictate the spatial and temporal control of certain aspects of the cell division cycle. In particular, septin-associated protein kinases couple cell cycle progression with cellular morphogenesis. Thus, septin-containing structures serve as signaling platforms that integrate a multitude of signals and coordinate key downstream networks required for cell cycle passage. This review summarizes what we currently understand about how the action of septin-associated protein kinases and their substrates control information flow to drive the cell cycle into and out of mitosis, to regulate bud growth, and especially to direct timely and efficient execution of cytokinesis and cell abscission. Thus, septin structures represent a regulatory node at the intersection of many signaling pathways. In addition, and importantly, the activities of certain septin-associated protein kinases also regulate the state of organization of the septins themselves, creating a complex feedback loop. |
| first_indexed | 2024-04-13T09:22:17Z |
| format | Article |
| id | doaj.art-95a1a99446c449babb50eb2fbe58c920 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T09:22:17Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-95a1a99446c449babb50eb2fbe58c9202022-12-22T02:52:33ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-11-01410.3389/fcell.2016.00119229014Septin-associated protein kinases in the yeast Saccharomyces cerevisiaeJeremy THORNER0University of California, BerkeleySeptins are a family of eukaryotic GTP-binding proteins that associate into linear rods, which, in turn, polymerize end-on-end into filaments and further assemble into other, more elaborate super-structures at discrete subcellular locations. Hence, septin-based ensembles are considered elements of the cytoskeleton. One function of these structures that has been well-documented in studies conducted in budding yeast Saccharomyces cerevisiae is to serve as a scaffold that recruits regulatory proteins, which dictate the spatial and temporal control of certain aspects of the cell division cycle. In particular, septin-associated protein kinases couple cell cycle progression with cellular morphogenesis. Thus, septin-containing structures serve as signaling platforms that integrate a multitude of signals and coordinate key downstream networks required for cell cycle passage. This review summarizes what we currently understand about how the action of septin-associated protein kinases and their substrates control information flow to drive the cell cycle into and out of mitosis, to regulate bud growth, and especially to direct timely and efficient execution of cytokinesis and cell abscission. Thus, septin structures represent a regulatory node at the intersection of many signaling pathways. In addition, and importantly, the activities of certain septin-associated protein kinases also regulate the state of organization of the septins themselves, creating a complex feedback loop.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00119/fullCell cycle; cell signaling; cytoskeletal element; morphology; protein phosphorylation |
| spellingShingle | Jeremy THORNER Septin-associated protein kinases in the yeast Saccharomyces cerevisiae Frontiers in Cell and Developmental Biology Cell cycle; cell signaling; cytoskeletal element; morphology; protein phosphorylation |
| title | Septin-associated protein kinases in the yeast Saccharomyces cerevisiae |
| title_full | Septin-associated protein kinases in the yeast Saccharomyces cerevisiae |
| title_fullStr | Septin-associated protein kinases in the yeast Saccharomyces cerevisiae |
| title_full_unstemmed | Septin-associated protein kinases in the yeast Saccharomyces cerevisiae |
| title_short | Septin-associated protein kinases in the yeast Saccharomyces cerevisiae |
| title_sort | septin associated protein kinases in the yeast saccharomyces cerevisiae |
| topic | Cell cycle; cell signaling; cytoskeletal element; morphology; protein phosphorylation |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00119/full |
| work_keys_str_mv | AT jeremythorner septinassociatedproteinkinasesintheyeastsaccharomycescerevisiae |