Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology
The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering capacity in response to an overall positive energy balance. Over the course of expansion, the adipose microenvironment undergoes continual remodeling to maintain its structural and functional integrity. Howeve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/15/2310 |
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| author | Simon Lecoutre Mélanie Lambert Krzysztof Drygalski Isabelle Dugail Salwan Maqdasy Mathieu Hautefeuille Karine Clément |
| author_facet | Simon Lecoutre Mélanie Lambert Krzysztof Drygalski Isabelle Dugail Salwan Maqdasy Mathieu Hautefeuille Karine Clément |
| author_sort | Simon Lecoutre |
| collection | DOAJ |
| description | The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering capacity in response to an overall positive energy balance. Over the course of expansion, the adipose microenvironment undergoes continual remodeling to maintain its structural and functional integrity. However, in the long run, adipose tissue remodeling, typically characterized by adipocyte hypertrophy, immune cells infiltration, fibrosis and changes in vascular architecture, generates mechanical stress on adipose cells. This mechanical stimulus is then transduced into a biochemical signal that alters adipose function through mechanotransduction. In this review, we describe the physical changes occurring during adipose tissue remodeling, and how they regulate adipose cell physiology and promote obesity-associated dysfunction in adipose tissue. |
| first_indexed | 2024-03-09T05:31:30Z |
| format | Article |
| id | doaj.art-95a2e0c77a764138b32ddb12bc219250 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:31:30Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-95a2e0c77a764138b32ddb12bc2192502023-12-03T12:32:04ZengMDPI AGCells2073-44092022-07-011115231010.3390/cells11152310Importance of the Microenvironment and Mechanosensing in Adipose Tissue BiologySimon Lecoutre0Mélanie Lambert1Krzysztof Drygalski2Isabelle Dugail3Salwan Maqdasy4Mathieu Hautefeuille5Karine Clément6Nutrition and Obesities: Systemic Approaches Research Group (Nutri-Omics), Sorbonne Université, INSERM, F-75013 Paris, FranceLabex Inflamex, Université Sorbonne Paris Nord, INSERM, F-93000 Bobigny, FranceNutrition and Obesities: Systemic Approaches Research Group (Nutri-Omics), Sorbonne Université, INSERM, F-75013 Paris, FranceNutrition and Obesities: Systemic Approaches Research Group (Nutri-Omics), Sorbonne Université, INSERM, F-75013 Paris, FranceDepartment of Medicine (H7), Karolinska Institutet Hospital, C2-94, 14186 Stockholm, SwedenLaboratoire de Biologie du Développement (UMR 7622), IBPS, Sorbonne Université, F-75005 Paris, FranceNutrition and Obesities: Systemic Approaches Research Group (Nutri-Omics), Sorbonne Université, INSERM, F-75013 Paris, FranceThe expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering capacity in response to an overall positive energy balance. Over the course of expansion, the adipose microenvironment undergoes continual remodeling to maintain its structural and functional integrity. However, in the long run, adipose tissue remodeling, typically characterized by adipocyte hypertrophy, immune cells infiltration, fibrosis and changes in vascular architecture, generates mechanical stress on adipose cells. This mechanical stimulus is then transduced into a biochemical signal that alters adipose function through mechanotransduction. In this review, we describe the physical changes occurring during adipose tissue remodeling, and how they regulate adipose cell physiology and promote obesity-associated dysfunction in adipose tissue.https://www.mdpi.com/2073-4409/11/15/2310adipose tissueobesitymechanobiology |
| spellingShingle | Simon Lecoutre Mélanie Lambert Krzysztof Drygalski Isabelle Dugail Salwan Maqdasy Mathieu Hautefeuille Karine Clément Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology Cells adipose tissue obesity mechanobiology |
| title | Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology |
| title_full | Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology |
| title_fullStr | Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology |
| title_full_unstemmed | Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology |
| title_short | Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology |
| title_sort | importance of the microenvironment and mechanosensing in adipose tissue biology |
| topic | adipose tissue obesity mechanobiology |
| url | https://www.mdpi.com/2073-4409/11/15/2310 |
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