Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases

Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases

Introduction: Sialic acids are important contributors to the polyanionic component of the glomerular filtration barrier, which regulates permeability selectivity. Pathologic glomerular hyposialylation, associated with podocyte effacement, has been implicated in human and mouse glomerulopathies. Oral...

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Main Authors: Marjan Huizing, Tal Yardeni, Federico Fuentes, May C.V. Malicdan, Petcharat Leoyklang, Alexander Volkov, Benjamin Dekel, Emily Brede, Jodi Blake, Alva Powell, Harish Chatrathi, Yair Anikster, Nuria Carrillo, William A. Gahl, Jeffrey B. Kopp
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Kidney International Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024919313956

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