Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
Background Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS) and its components changes over time, we aimed to investigate the association of the cumulative exposure to MetS and its components with the risk of dementia. Methods Adults (n...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2021-04-01
|
| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2020-935.pdf |
| _version_ | 1818387900505522176 |
|---|---|
| author | Yunjung Cho Kyungdo Han Da Hye Kim Yong-Moon Park Kun-Ho Yoon Mee Kyoung Kim Seung-Hwan Lee |
| author_facet | Yunjung Cho Kyungdo Han Da Hye Kim Yong-Moon Park Kun-Ho Yoon Mee Kyoung Kim Seung-Hwan Lee |
| author_sort | Yunjung Cho |
| collection | DOAJ |
| description | Background Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS) and its components changes over time, we aimed to investigate the association of the cumulative exposure to MetS and its components with the risk of dementia. Methods Adults (n=1,492,776; ≥45-years-old) who received health examinations for 4 consecutive years were identified from a nationwide population-based cohort in Korea. Two exposure-weighted scores were calculated: cumulative number of MetS diagnoses (MetS exposure score, range of 0 to 4) and the composite of its five components (MetS component exposure score, range of 0 to 20). Hazard ratio (HR) and 95% confidence interval (CI) values for dementia were analyzed using the multivariable Cox proportional-hazards model. Results Overall, 47.1% of subjects were diagnosed with MetS at least once, and 11.5% had persistent MetS. During the mean 5.2 years of follow-up, there were 7,341 cases (0.5%) of incident dementia. There was a stepwise increase in the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia with increasing MetS exposure score and MetS component exposure score (each P for trend <0.0001). The HR of all-cause dementia was 2.62 (95% CI, 1.87 to 3.68) in subjects with a MetS component exposure score of 20 compared with those with a score of 0. People fulfilling only one MetS component out of 20 already had an approximately 40% increased risk of all-cause dementia and Alzheimer’s disease. Conclusion More cumulative exposure to metabolic disturbances was associated with a higher risk of dementia. Of note, even minimal exposure to MetS components had a significant effect on the risk of dementia. |
| first_indexed | 2024-12-14T04:17:17Z |
| format | Article |
| id | doaj.art-95a3e7a207e14896b91703f93ee94d61 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-14T04:17:17Z |
| publishDate | 2021-04-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-95a3e7a207e14896b91703f93ee94d612022-12-21T23:17:29ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-04-0136242443510.3803/EnM.2020.9352153Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based StudyYunjung Cho0Kyungdo Han1Da Hye Kim2Yong-Moon Park3Kun-Ho Yoon4Mee Kyoung Kim5Seung-Hwan Lee6 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS) and its components changes over time, we aimed to investigate the association of the cumulative exposure to MetS and its components with the risk of dementia. Methods Adults (n=1,492,776; ≥45-years-old) who received health examinations for 4 consecutive years were identified from a nationwide population-based cohort in Korea. Two exposure-weighted scores were calculated: cumulative number of MetS diagnoses (MetS exposure score, range of 0 to 4) and the composite of its five components (MetS component exposure score, range of 0 to 20). Hazard ratio (HR) and 95% confidence interval (CI) values for dementia were analyzed using the multivariable Cox proportional-hazards model. Results Overall, 47.1% of subjects were diagnosed with MetS at least once, and 11.5% had persistent MetS. During the mean 5.2 years of follow-up, there were 7,341 cases (0.5%) of incident dementia. There was a stepwise increase in the risk of all-cause dementia, Alzheimer’s disease, and vascular dementia with increasing MetS exposure score and MetS component exposure score (each P for trend <0.0001). The HR of all-cause dementia was 2.62 (95% CI, 1.87 to 3.68) in subjects with a MetS component exposure score of 20 compared with those with a score of 0. People fulfilling only one MetS component out of 20 already had an approximately 40% increased risk of all-cause dementia and Alzheimer’s disease. Conclusion More cumulative exposure to metabolic disturbances was associated with a higher risk of dementia. Of note, even minimal exposure to MetS components had a significant effect on the risk of dementia.http://www.e-enm.org/upload/pdf/enm-2020-935.pdfalzheimer diseasedementiametabolic syndrome |
| spellingShingle | Yunjung Cho Kyungdo Han Da Hye Kim Yong-Moon Park Kun-Ho Yoon Mee Kyoung Kim Seung-Hwan Lee Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study Endocrinology and Metabolism alzheimer disease dementia metabolic syndrome |
| title | Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study |
| title_full | Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study |
| title_fullStr | Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study |
| title_full_unstemmed | Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study |
| title_short | Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study |
| title_sort | cumulative exposure to metabolic syndrome components and the risk of dementia a nationwide population based study |
| topic | alzheimer disease dementia metabolic syndrome |
| url | http://www.e-enm.org/upload/pdf/enm-2020-935.pdf |
| work_keys_str_mv | AT yunjungcho cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT kyungdohan cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT dahyekim cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT yongmoonpark cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT kunhoyoon cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT meekyoungkim cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy AT seunghwanlee cumulativeexposuretometabolicsyndromecomponentsandtheriskofdementiaanationwidepopulationbasedstudy |