Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis
Abstract Chronic Helicobacter pylori infection is a critical risk factor for gastric cancer (GC). However, only 1–3 % of people with H. pylori develop GC. In gastric carcinogenesis, non-H. pylori bacteria in the stomach might interact with H. pylori. Bacterial dysbiosis in the stomach can strengthen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12866-021-02315-x |
| _version_ | 1819111101422370816 |
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| author | Seyedeh Zahra Bakhti Saeid Latifi-Navid |
| author_facet | Seyedeh Zahra Bakhti Saeid Latifi-Navid |
| author_sort | Seyedeh Zahra Bakhti |
| collection | DOAJ |
| description | Abstract Chronic Helicobacter pylori infection is a critical risk factor for gastric cancer (GC). However, only 1–3 % of people with H. pylori develop GC. In gastric carcinogenesis, non-H. pylori bacteria in the stomach might interact with H. pylori. Bacterial dysbiosis in the stomach can strengthen gastric neoplasia development via generating tumor-promoting metabolites, DNA damaging, suppressing antitumor immunity, and activating oncogenic signaling pathways. Other bacterial species may generate short-chain fatty acids like butyrate that may inhibit carcinogenesis and inflammation in the human stomach. The present article aimed at providing a comprehensive overview of the effects of gut microbiota and H. pylori on the development of GC. Next, the potential mechanisms of intestinal microbiota were discussed in gastric carcinogenesis. We also disserted the complicated interactions between H. pylori, intestinal microbiota, and host in gastric carcinogenesis, thus helping us to design new strategies for preventing, diagnosing, and treating GC. |
| first_indexed | 2024-12-22T03:52:16Z |
| format | Article |
| id | doaj.art-95a47aa0822049ab9b74ee7eb9f4a103 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-22T03:52:16Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-95a47aa0822049ab9b74ee7eb9f4a1032022-12-21T18:39:58ZengBMCBMC Microbiology1471-21802021-09-0121111610.1186/s12866-021-02315-xInterplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesisSeyedeh Zahra Bakhti0Saeid Latifi-Navid1Department of Biology, Faculty of Sciences, University of Mohaghegh ArdabiliDepartment of Biology, Faculty of Sciences, University of Mohaghegh ArdabiliAbstract Chronic Helicobacter pylori infection is a critical risk factor for gastric cancer (GC). However, only 1–3 % of people with H. pylori develop GC. In gastric carcinogenesis, non-H. pylori bacteria in the stomach might interact with H. pylori. Bacterial dysbiosis in the stomach can strengthen gastric neoplasia development via generating tumor-promoting metabolites, DNA damaging, suppressing antitumor immunity, and activating oncogenic signaling pathways. Other bacterial species may generate short-chain fatty acids like butyrate that may inhibit carcinogenesis and inflammation in the human stomach. The present article aimed at providing a comprehensive overview of the effects of gut microbiota and H. pylori on the development of GC. Next, the potential mechanisms of intestinal microbiota were discussed in gastric carcinogenesis. We also disserted the complicated interactions between H. pylori, intestinal microbiota, and host in gastric carcinogenesis, thus helping us to design new strategies for preventing, diagnosing, and treating GC.https://doi.org/10.1186/s12866-021-02315-xH. pylorigut microbiotainteractiongastric carcinogenesis |
| spellingShingle | Seyedeh Zahra Bakhti Saeid Latifi-Navid Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis BMC Microbiology H. pylori gut microbiota interaction gastric carcinogenesis |
| title | Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis |
| title_full | Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis |
| title_fullStr | Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis |
| title_full_unstemmed | Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis |
| title_short | Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis |
| title_sort | interplay and cooperation of helicobacter pylori and gut microbiota in gastric carcinogenesis |
| topic | H. pylori gut microbiota interaction gastric carcinogenesis |
| url | https://doi.org/10.1186/s12866-021-02315-x |
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