Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the par...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12789-z |
| _version_ | 1819126352377282560 |
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| author | Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons |
| author_facet | Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons |
| author_sort | Minou Djannatian |
| collection | DOAJ |
| description | It remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and myelin wrapping, and that in the combined absence of these molecules myelin sheaths are misplaced. |
| first_indexed | 2024-12-22T07:54:40Z |
| format | Article |
| id | doaj.art-95a5bb57aa1d4978820134d929b49f85 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:54:40Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-95a5bb57aa1d4978820134d929b49f852022-12-21T18:33:24ZengNature PortfolioNature Communications2041-17232019-10-0110111510.1038/s41467-019-12789-zTwo adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNSMinou Djannatian0Sebastian Timmler1Martina Arends2Manja Luckner3Marie-Theres Weil4Ioannis Alexopoulos5Nicolas Snaidero6Bettina Schmid7Thomas Misgeld8Wiebke Möbius9Martina Schifferer10Elior Peles11Mikael Simons12Institute of Neuronal Cell Biology, Technical University MunichInstitute of Neuronal Cell Biology, Technical University MunichInstitute of Neuronal Cell Biology, Technical University MunichInstitute of Neuronal Cell Biology, Technical University MunichDepartment of Neurogenetics, Max Planck Institute of Experimental MedicineInstitute of Neuronal Cell Biology, Technical University MunichInstitute of Neuronal Cell Biology, Technical University MunichGerman Center for Neurodegenerative Diseases (DZNE)Institute of Neuronal Cell Biology, Technical University MunichDepartment of Neurogenetics, Max Planck Institute of Experimental MedicineInstitute of Neuronal Cell Biology, Technical University MunichDepartment of Molecular Cell Biology, The Weizmann Institute of ScienceInstitute of Neuronal Cell Biology, Technical University MunichIt remains unclear how myelin is targeted specifically to axons while sparing neuronal cell bodies and dendrites, or how small gaps, the nodes of Ranvier, are left unmyelinated along the axon. In this study, authors used genetic analyses in zebrafish and mice to demonstrate that molecules of the paranodal axo-glial junction act jointly with molecules of the internodal domain to regulate axonal interactions and myelin wrapping, and that in the combined absence of these molecules myelin sheaths are misplaced.https://doi.org/10.1038/s41467-019-12789-z |
| spellingShingle | Minou Djannatian Sebastian Timmler Martina Arends Manja Luckner Marie-Theres Weil Ioannis Alexopoulos Nicolas Snaidero Bettina Schmid Thomas Misgeld Wiebke Möbius Martina Schifferer Elior Peles Mikael Simons Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS Nature Communications |
| title | Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS |
| title_full | Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS |
| title_fullStr | Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS |
| title_full_unstemmed | Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS |
| title_short | Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS |
| title_sort | two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the cns |
| url | https://doi.org/10.1038/s41467-019-12789-z |
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