3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY
Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose m...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2015-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930713/view |
| _version_ | 1818539044998479872 |
|---|---|
| author | Ben Sörensen* Boy Houben Tos Berendschot Jan Schouten Bram Kroon Carla van der Kallen Ronald Henry Annemarie Koster Pieter Dagnelie Nicolaas Schaper Miranda Schram Coen Stehouwer |
| author_facet | Ben Sörensen* Boy Houben Tos Berendschot Jan Schouten Bram Kroon Carla van der Kallen Ronald Henry Annemarie Koster Pieter Dagnelie Nicolaas Schaper Miranda Schram Coen Stehouwer |
| author_sort | Ben Sörensen* |
| collection | DOAJ |
| description | Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose metabolism are not available. We investigated this using the retinal arteriolar dilator response to flicker light.
Methods: In a population-based study (n = 2205), we determined retinal %-dilation (Dynamic Vessel Analyzer; Imedos, Germany) and glucose metabolism status (OGTT; classified as normal (NGM), IGM or DM2). Differences were compared with multivariable regression adjusted for age, sex, BMI, smoking, systolic-BP, lipid profile, retinopathy, (micro)albuminuria, the use of lipid-modifying and/or blood-pressure-lowering medication and prior cardiovascular disease.
Results: 1263 individuals had NGM (42% men, aged 58 ± 8 years (mean ± SD)), 336 IGM (61% men, aged 61 ± 7 years) and 606 (due to oversampling) DM2 (69% men, aged 63 ± 8 years). Arteriolar %-dilation was median 3.51, IQR 1.47 to 5.95, range −5.69 to +19.71. %-dilation (mean ± SD) was 4.42 ± 3.45 in NGM, 3.77 ± 3.06 in IGM, and 3.26 ± 3.27 in DM2. Adjusted analyses showed decreased %-dilation in IGM (β = −0.461, p = 0.03) and DM2 (β = 0.559, p = 0.01) vs NGM.
Conclusion: IGM and DM2 are associated with reduced flicker-light-induced retinal arteriolar dilation, independently of major cardiovascular risk factors. These findings support the concept that MVD precedes and thus may contribute to DM2. |
| first_indexed | 2024-12-11T21:36:51Z |
| format | Article |
| id | doaj.art-95a6baa2ec894ef4994aa4836d9cac1a |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-12-11T21:36:51Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-95a6baa2ec894ef4994aa4836d9cac1a2022-12-22T00:49:58ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.0143.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDYBen Sörensen*Boy HoubenTos BerendschotJan SchoutenBram KroonCarla van der KallenRonald HenryAnnemarie KosterPieter DagnelieNicolaas SchaperMiranda SchramCoen StehouwerAim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). However, population-based studies of MVD and glucose metabolism are not available. We investigated this using the retinal arteriolar dilator response to flicker light. Methods: In a population-based study (n = 2205), we determined retinal %-dilation (Dynamic Vessel Analyzer; Imedos, Germany) and glucose metabolism status (OGTT; classified as normal (NGM), IGM or DM2). Differences were compared with multivariable regression adjusted for age, sex, BMI, smoking, systolic-BP, lipid profile, retinopathy, (micro)albuminuria, the use of lipid-modifying and/or blood-pressure-lowering medication and prior cardiovascular disease. Results: 1263 individuals had NGM (42% men, aged 58 ± 8 years (mean ± SD)), 336 IGM (61% men, aged 61 ± 7 years) and 606 (due to oversampling) DM2 (69% men, aged 63 ± 8 years). Arteriolar %-dilation was median 3.51, IQR 1.47 to 5.95, range −5.69 to +19.71. %-dilation (mean ± SD) was 4.42 ± 3.45 in NGM, 3.77 ± 3.06 in IGM, and 3.26 ± 3.27 in DM2. Adjusted analyses showed decreased %-dilation in IGM (β = −0.461, p = 0.03) and DM2 (β = 0.559, p = 0.01) vs NGM. Conclusion: IGM and DM2 are associated with reduced flicker-light-induced retinal arteriolar dilation, independently of major cardiovascular risk factors. These findings support the concept that MVD precedes and thus may contribute to DM2.https://www.atlantis-press.com/article/125930713/view |
| spellingShingle | Ben Sörensen* Boy Houben Tos Berendschot Jan Schouten Bram Kroon Carla van der Kallen Ronald Henry Annemarie Koster Pieter Dagnelie Nicolaas Schaper Miranda Schram Coen Stehouwer 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY Artery Research |
| title | 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY |
| title_full | 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY |
| title_fullStr | 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY |
| title_full_unstemmed | 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY |
| title_short | 3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY |
| title_sort | 3 1 prediabetes is associated with impaired retinal vasodilation the maastricht study |
| url | https://www.atlantis-press.com/article/125930713/view |
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