Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders

Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders

Pemphigoid diseases (PD) are autoimmune skin blistering diseases characterized by autoantibodies directed against proteins of the cutaneous basement membrane zone (BMZ). One of the major antigens is type XVII collagen (BP180), a transmembrane glycoprotein, which is targeted in four PDs: bullous pemp...

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Bibliographic Details
Main Authors: Bianca Opelka, Enno Schmidt, Stephanie Goletz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
BP180
epitopes
pemphigoid
autoimmunity
bullous disease
autoantigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.948108/full

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