Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain
This study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes and impairment in body weight gain following noise-exposure in Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, and V were exp...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | Experimental Results |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2516712X21000307/type/journal_article |
| _version_ | 1811156315451424768 |
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| author | Isaac Oluwatobi Akefe Joseph Olusegun Ayo Victor Olusegun Sinkalu Michael Nevels |
| author_facet | Isaac Oluwatobi Akefe Joseph Olusegun Ayo Victor Olusegun Sinkalu Michael Nevels |
| author_sort | Isaac Oluwatobi Akefe |
| collection | DOAJ |
| description | This study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes and impairment in body weight gain following noise-exposure in Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, and V were exposed to noise stress, induced by exposing rats to 100 dB (4 hr/day) for 15 days, from days 33 to 48 after starting the drug treatments. Treatment with kaempferol and/or zinc mitigated noise-induced deficits in body weight gain, and levels of serum lipid and protein fractions. The combined treatment significantly (p < .05) decreased malondialdehyde concentration in kaempferol + zinc gluconate treated group, compared to the group administered deionized water + noise. This result demonstrates that biochemical dyshomeostasis and lipid peroxidation may be involved in the molecular mechanism underlying noise stress and the assortment of kaempferol and zinc gluconate produced an improved mitigating outcome in Wistar rats. |
| first_indexed | 2024-04-10T04:48:25Z |
| format | Article |
| id | doaj.art-95a783829351404588d03e08b7408fb3 |
| institution | Directory Open Access Journal |
| issn | 2516-712X |
| language | English |
| last_indexed | 2024-04-10T04:48:25Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Experimental Results |
| spelling | doaj.art-95a783829351404588d03e08b7408fb32023-03-09T12:34:19ZengCambridge University PressExperimental Results2516-712X2021-01-01210.1017/exp.2021.30Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gainIsaac Oluwatobi Akefe0https://orcid.org/0000-0003-4738-0701Joseph Olusegun Ayo1Victor Olusegun Sinkalu2Michael Nevels3Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Jos, Nigeria Department of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, NigeriaDepartment of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, NigeriaDepartment of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, NigeriaUniversity of St Andrews, Biomolecular Sciences Building, Fife, United Kingdom of Great Britain and Northern Ireland, KY16 9STThis study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes and impairment in body weight gain following noise-exposure in Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, and V were exposed to noise stress, induced by exposing rats to 100 dB (4 hr/day) for 15 days, from days 33 to 48 after starting the drug treatments. Treatment with kaempferol and/or zinc mitigated noise-induced deficits in body weight gain, and levels of serum lipid and protein fractions. The combined treatment significantly (p < .05) decreased malondialdehyde concentration in kaempferol + zinc gluconate treated group, compared to the group administered deionized water + noise. This result demonstrates that biochemical dyshomeostasis and lipid peroxidation may be involved in the molecular mechanism underlying noise stress and the assortment of kaempferol and zinc gluconate produced an improved mitigating outcome in Wistar rats.https://www.cambridge.org/core/product/identifier/S2516712X21000307/type/journal_articlebiochemicalbodyweightkaempferolnoiseoxidative stressWistar ratszinc |
| spellingShingle | Isaac Oluwatobi Akefe Joseph Olusegun Ayo Victor Olusegun Sinkalu Michael Nevels Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain Experimental Results biochemical bodyweight kaempferol noise oxidative stress Wistar rats zinc |
| title | Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain |
| title_full | Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain |
| title_fullStr | Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain |
| title_full_unstemmed | Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain |
| title_short | Assortment of kaempferol and zinc gluconate improves noise-induced biochemical imbalance and deficits in body weight gain |
| title_sort | assortment of kaempferol and zinc gluconate improves noise induced biochemical imbalance and deficits in body weight gain |
| topic | biochemical bodyweight kaempferol noise oxidative stress Wistar rats zinc |
| url | https://www.cambridge.org/core/product/identifier/S2516712X21000307/type/journal_article |
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