Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are released into cytosol due to lysosomal membrane permeabilization (LMP), where they trigger apoptosis via the lysosomal-mitochondrial pathway of apoptosis. Herein, the mechanism of LMP was investigated. We found t...

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Bibliographic Details
Main Authors: Kai Zhao, Hejiang Zhou, Xingyu Zhao, Dennis W. Wolff, Yaping Tu, Huili Liu, Taotao Wei, Fuyu Yang
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Journal of Lipid Research
Subjects:
Bid
chymotrypsin
lysosome
enzymology
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520431876

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