Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
Background: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long-survivors after allo-HCT. Dysregulation of immune reconstit...
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Format: | Article |
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Tehran University of Medical Sciences
2020-01-01
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Series: | International Journal of Hematology-Oncology and Stem Cell Research |
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Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1107 |
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author | Hitoshi Yoshida Midori Koike Yuma Tada Keiichi Nakata Akihisa Hino Shigeo Fuji Hiroaki Masaie Chihiro Oka Akemi Higeno Atushi Idota Tomoyuki Yamasaki Jun Ishikawa |
author_facet | Hitoshi Yoshida Midori Koike Yuma Tada Keiichi Nakata Akihisa Hino Shigeo Fuji Hiroaki Masaie Chihiro Oka Akemi Higeno Atushi Idota Tomoyuki Yamasaki Jun Ishikawa |
author_sort | Hitoshi Yoshida |
collection | DOAJ |
description | Background: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long-survivors after allo-HCT. Dysregulation of immune reconstitution has been reported to be involved in the pathogenesis of chronic GVHD. Differences of immune reconstitution between cord blood transplantation (CBT) and unrelated bone marrow transplantation (uBMT) remain unclear in long-term survivors. We investigated immune reconstitution in patients who survive for more than 2 years after CBT (n=21) or uBMT (n=20) without relapse of underlying disease.
Materials and Methods: Using flowcytomeric analysis of peripheral blood, we investigated immune reconstitution of T cells, B cells, and NK cells between CBT and uBMT patients. We collected clinical data regarding allo-HCT and examined the relation of immune reconstitution to the development of chronic GVHD.
Results: Between CBT and uBMT patients, we found significant differences in absolute cell number of CD8+ as well as CD19+ cell and CD4/CD8 ratio even more than 2 years after allo-HCT. Among uBMT patients, absolute cell number of naïve CD4+ cell was significantly lower in patients with chronic GVHD. In addition, we found significant differences in absolute cell number of CD19+ cell, especially naïve B cell between patients with and without chronic GVHD in both CBT and uBMT patients.
Conclusion: These results suggest that differences of immune recovery between CBT and uBMT patients may exist even in patients who survive for more than 2 years and might be related to the development of chronic GVHD. |
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institution | Directory Open Access Journal |
issn | 2008-2207 |
language | English |
last_indexed | 2024-03-12T08:24:51Z |
publishDate | 2020-01-01 |
publisher | Tehran University of Medical Sciences |
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series | International Journal of Hematology-Oncology and Stem Cell Research |
spelling | doaj.art-95aacee902ef4e93941f1fa45c0e918d2023-09-02T18:11:46ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072020-01-0114110.18502/ijhoscr.v14i1.2323Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host DiseaseHitoshi Yoshida0Midori Koike1Yuma Tada2Keiichi Nakata3Akihisa Hino4Shigeo Fuji5Hiroaki Masaie6Chihiro Oka7Akemi Higeno8Atushi Idota9Tomoyuki Yamasaki10Jun Ishikawa11Department of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanDepartment of Laboratory, Osaka International Cancer Institute, Osaka, JapanDepartment of Laboratory, Osaka International Cancer Institute, Osaka, JapanDepartment of Laboratory, Osaka International Cancer Institute, Osaka, JapanDepartment of Laboratory, Osaka International Cancer Institute, Osaka, JapanDepartment of Hematology , Osaka International Cancer Institute, Osaka, JapanBackground: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long-survivors after allo-HCT. Dysregulation of immune reconstitution has been reported to be involved in the pathogenesis of chronic GVHD. Differences of immune reconstitution between cord blood transplantation (CBT) and unrelated bone marrow transplantation (uBMT) remain unclear in long-term survivors. We investigated immune reconstitution in patients who survive for more than 2 years after CBT (n=21) or uBMT (n=20) without relapse of underlying disease. Materials and Methods: Using flowcytomeric analysis of peripheral blood, we investigated immune reconstitution of T cells, B cells, and NK cells between CBT and uBMT patients. We collected clinical data regarding allo-HCT and examined the relation of immune reconstitution to the development of chronic GVHD. Results: Between CBT and uBMT patients, we found significant differences in absolute cell number of CD8+ as well as CD19+ cell and CD4/CD8 ratio even more than 2 years after allo-HCT. Among uBMT patients, absolute cell number of naïve CD4+ cell was significantly lower in patients with chronic GVHD. In addition, we found significant differences in absolute cell number of CD19+ cell, especially naïve B cell between patients with and without chronic GVHD in both CBT and uBMT patients. Conclusion: These results suggest that differences of immune recovery between CBT and uBMT patients may exist even in patients who survive for more than 2 years and might be related to the development of chronic GVHD.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1107Immune reconstitution; Cord blood transplantation; Unrelated bone marrow transplantation; Chronic GVHD |
spellingShingle | Hitoshi Yoshida Midori Koike Yuma Tada Keiichi Nakata Akihisa Hino Shigeo Fuji Hiroaki Masaie Chihiro Oka Akemi Higeno Atushi Idota Tomoyuki Yamasaki Jun Ishikawa Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease International Journal of Hematology-Oncology and Stem Cell Research Immune reconstitution; Cord blood transplantation; Unrelated bone marrow transplantation; Chronic GVHD |
title | Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease |
title_full | Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease |
title_fullStr | Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease |
title_full_unstemmed | Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease |
title_short | Different Immune Reconstitution between Cord Blood and unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease |
title_sort | different immune reconstitution between cord blood and unrelated bone marrow transplantation with relation to chronic graft versus host disease |
topic | Immune reconstitution; Cord blood transplantation; Unrelated bone marrow transplantation; Chronic GVHD |
url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1107 |
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