A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet
Objective: Autism spectrum disorders (ASDs) appear in the early stages of neurodevelopment, and they remain constant throughout life. Currently, due to limitations in ASDs treatment, alternative approaches, such as nutritional interventions, have frequently been implemented. The aim of this narrativ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/9/1797 |
| _version_ | 1797503459258269696 |
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| author | Pablo José González-Domenech Francisco Diaz-Atienza Luis Gutiérrez-Rojas María Luisa Fernández-Soto Carmen María González-Domenech |
| author_facet | Pablo José González-Domenech Francisco Diaz-Atienza Luis Gutiérrez-Rojas María Luisa Fernández-Soto Carmen María González-Domenech |
| author_sort | Pablo José González-Domenech |
| collection | DOAJ |
| description | Objective: Autism spectrum disorders (ASDs) appear in the early stages of neurodevelopment, and they remain constant throughout life. Currently, due to limitations in ASDs treatment, alternative approaches, such as nutritional interventions, have frequently been implemented. The aim of this narrative review is to gather the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis. Results: Our literature search focused on the gluten- and casein-free (GFCF) diet. The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD. Protocols and procedures for assessing risk and safety are also needed. Future lines: Prospective and controlled research studies with larger sample sizes and longer follow-up times are scarce and needed. In addition, studies considering an assessment of intestinal permeability, bacterial population, enzymatic, and inflammatory gastrointestinal activity are interesting to identify possible responders. Besides brain imaging techniques, genetic tests can also contribute as markers to evaluate the comorbidity of gastrointestinal symptoms. |
| first_indexed | 2024-03-10T03:50:58Z |
| format | Article |
| id | doaj.art-95ab006d72c34496acd41c99b0ecfb54 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:50:58Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-95ab006d72c34496acd41c99b0ecfb542023-11-23T08:58:35ZengMDPI AGNutrients2072-66432022-04-01149179710.3390/nu14091797A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the DietPablo José González-Domenech0Francisco Diaz-Atienza1Luis Gutiérrez-Rojas2María Luisa Fernández-Soto3Carmen María González-Domenech4Department of Psychiatry, University of Granada, Health Technology Park, Av. de la Investigación, 11, 18071 Granada, SpainDepartment of Psychiatry, University of Granada, Health Technology Park, Av. de la Investigación, 11, 18071 Granada, SpainDepartment of Psychiatry, University of Granada, Health Technology Park, Av. de la Investigación, 11, 18071 Granada, SpainDepartment of Medicine, University of Granada, Health Technology Park, Av. de la Investigación, 11, 18071 Granada, SpainDepartment of Microbiology, University of Málaga, Louis Pasteur Avenue, 29010 Málaga, SpainObjective: Autism spectrum disorders (ASDs) appear in the early stages of neurodevelopment, and they remain constant throughout life. Currently, due to limitations in ASDs treatment, alternative approaches, such as nutritional interventions, have frequently been implemented. The aim of this narrative review is to gather the most relevant and updated studies about dietary interventions related to ASDs etiopathogenesis. Results: Our literature search focused on the gluten- and casein-free (GFCF) diet. The literature found shows the inexistence of enough scientific evidence to support a general recommendation of dietary intervention in children with ASD. Protocols and procedures for assessing risk and safety are also needed. Future lines: Prospective and controlled research studies with larger sample sizes and longer follow-up times are scarce and needed. In addition, studies considering an assessment of intestinal permeability, bacterial population, enzymatic, and inflammatory gastrointestinal activity are interesting to identify possible responders. Besides brain imaging techniques, genetic tests can also contribute as markers to evaluate the comorbidity of gastrointestinal symptoms.https://www.mdpi.com/2072-6643/14/9/1797dietglutencaseinautism spectrum disorders |
| spellingShingle | Pablo José González-Domenech Francisco Diaz-Atienza Luis Gutiérrez-Rojas María Luisa Fernández-Soto Carmen María González-Domenech A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet Nutrients diet gluten casein autism spectrum disorders |
| title | A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet |
| title_full | A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet |
| title_fullStr | A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet |
| title_full_unstemmed | A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet |
| title_short | A Narrative Review about Autism Spectrum Disorders and Exclusion of Gluten and Casein from the Diet |
| title_sort | narrative review about autism spectrum disorders and exclusion of gluten and casein from the diet |
| topic | diet gluten casein autism spectrum disorders |
| url | https://www.mdpi.com/2072-6643/14/9/1797 |
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