Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

Effective Anti-tumor Response by TIGIT Blockade Associated With FcγR Engagement and Myeloid Cell Activation

The molecule “T cell immunoreceptor with immunoglobulin and ITIM domain,” or TIGIT, has recently received much attention as a promising target in the treatment of various malignancies. In spite of the quick progression of anti-TIGIT antibodies into clinical testing both as monotherapy and in combina...

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Những tác giả chính: Jin-Hwan Han, Mingmei Cai, Jeffery Grein, Samanthi Perera, Hongmei Wang, Mike Bigler, Roenna Ueda, Thomas W. Rosahl, Elaine Pinheiro, Drake LaFace, Wolfgang Seghezzi, Sybil M. Genther Williams
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Frontiers Media S.A. 2020-10-01
Loạt:Frontiers in Immunology
Những chủ đề:
TIGIT
FcγR
myeloid cells
combination cancer immunotherapy
costimulatory molecules
immune checkpoint blockade
Truy cập trực tuyến:https://www.frontiersin.org/article/10.3389/fimmu.2020.573405/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.573405/full

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