Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure
<p>Abstract</p> <p>Background</p> <p>Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1) whether an...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | http://www.cardiab.com/content/11/1/118 |
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| author | Sakamoto Masaya Suzuki Hirofumi Hayashi Takeshi Iuchi Hiroyuki Isaka Tsuyoshi Sakamoto Noriko Kayama Yosuke Tojo Katsuyoshi Yoshimura Michihiro Utsunomiya Kazunori |
| author_facet | Sakamoto Masaya Suzuki Hirofumi Hayashi Takeshi Iuchi Hiroyuki Isaka Tsuyoshi Sakamoto Noriko Kayama Yosuke Tojo Katsuyoshi Yoshimura Michihiro Utsunomiya Kazunori |
| author_sort | Sakamoto Masaya |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1) whether an ARB (candesartan) decreases values for inflammatory parameters in hypertensive patients with type 2 diabetes mellitus of long duration accompanied by arteriosclerosis and (2) whether there any predictors of which patients would receive the benefits of organ protection by candesartan.</p> <p>Methods</p> <p>We administered candesartan therapy (12 mg daily) for 6 months and evaluated whether there was improvement in serum inflammatory parameters high molecular weight adiponectin (HMW-ADN), plasminogen activator inhibitor-1 (PAI-1), highly sensitive C-reactive protein (Hs-CRP), vascular cell adhesion molecule-1 (VCAM-1) in serum and urinary-8-hydroxydeoxyguanosine (U-8-OHdG). We then analyzed the relationship between the degree of lowering of blood pressure and inflammatory factors and the relationship between pulse pressure and inflammatory factors. Finally, we analyzed predictive factors in patients who received the protective benefit of candesartan.</p> <p>Results</p> <p>After 6 months of treatment, significant improvements from baseline values were observed in all patients in HMW-ADN and PAI-1 but not in Hs-CRP, VCAM-1 and U-8-OHdG. Multilinear regression analysis was performed to determine which factors could best predict changes in HMW-ADN and PAI-1. Changes in blood pressure were not significant predictors of changes in metabolic factors in all patients. We found that the group with baseline pulse pressure <60 mmHg had improved HMW-ADN and PAI-1 values compared with the group with baseline pulse pressure ≥ 60 mmHg. These results suggest that pulse pressure at baseline could be predictive of changes in HMW-ADN and PAI-1.</p> <p>Conclusions</p> <p>Candesartan improved inflammatory parameters (HMW-ADN and PAI-1) in hypertensive patients with type 2 diabetes mellitus of long duration independent of blood pressure changes. Patients with pulse pressure <60 mmHg might receive protective benefits by candesartan.</p> <p>Trial registration</p> <p>UMIN000007921</p> |
| first_indexed | 2024-12-12T12:40:17Z |
| format | Article |
| id | doaj.art-95abb5755f6b40e1ad15ed4a679543d8 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-12T12:40:17Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-95abb5755f6b40e1ad15ed4a679543d82022-12-22T00:24:14ZengBMCCardiovascular Diabetology1475-28402012-10-0111111810.1186/1475-2840-11-118Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressureSakamoto MasayaSuzuki HirofumiHayashi TakeshiIuchi HiroyukiIsaka TsuyoshiSakamoto NorikoKayama YosukeTojo KatsuyoshiYoshimura MichihiroUtsunomiya Kazunori<p>Abstract</p> <p>Background</p> <p>Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1) whether an ARB (candesartan) decreases values for inflammatory parameters in hypertensive patients with type 2 diabetes mellitus of long duration accompanied by arteriosclerosis and (2) whether there any predictors of which patients would receive the benefits of organ protection by candesartan.</p> <p>Methods</p> <p>We administered candesartan therapy (12 mg daily) for 6 months and evaluated whether there was improvement in serum inflammatory parameters high molecular weight adiponectin (HMW-ADN), plasminogen activator inhibitor-1 (PAI-1), highly sensitive C-reactive protein (Hs-CRP), vascular cell adhesion molecule-1 (VCAM-1) in serum and urinary-8-hydroxydeoxyguanosine (U-8-OHdG). We then analyzed the relationship between the degree of lowering of blood pressure and inflammatory factors and the relationship between pulse pressure and inflammatory factors. Finally, we analyzed predictive factors in patients who received the protective benefit of candesartan.</p> <p>Results</p> <p>After 6 months of treatment, significant improvements from baseline values were observed in all patients in HMW-ADN and PAI-1 but not in Hs-CRP, VCAM-1 and U-8-OHdG. Multilinear regression analysis was performed to determine which factors could best predict changes in HMW-ADN and PAI-1. Changes in blood pressure were not significant predictors of changes in metabolic factors in all patients. We found that the group with baseline pulse pressure <60 mmHg had improved HMW-ADN and PAI-1 values compared with the group with baseline pulse pressure ≥ 60 mmHg. These results suggest that pulse pressure at baseline could be predictive of changes in HMW-ADN and PAI-1.</p> <p>Conclusions</p> <p>Candesartan improved inflammatory parameters (HMW-ADN and PAI-1) in hypertensive patients with type 2 diabetes mellitus of long duration independent of blood pressure changes. Patients with pulse pressure <60 mmHg might receive protective benefits by candesartan.</p> <p>Trial registration</p> <p>UMIN000007921</p>http://www.cardiab.com/content/11/1/118CandesartanAngiotensin receptor blockersType 2 diabetes mellitusInflammatory parametersPulse pressure |
| spellingShingle | Sakamoto Masaya Suzuki Hirofumi Hayashi Takeshi Iuchi Hiroyuki Isaka Tsuyoshi Sakamoto Noriko Kayama Yosuke Tojo Katsuyoshi Yoshimura Michihiro Utsunomiya Kazunori Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure Cardiovascular Diabetology Candesartan Angiotensin receptor blockers Type 2 diabetes mellitus Inflammatory parameters Pulse pressure |
| title | Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| title_full | Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| title_fullStr | Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| title_full_unstemmed | Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| title_short | Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| title_sort | effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure |
| topic | Candesartan Angiotensin receptor blockers Type 2 diabetes mellitus Inflammatory parameters Pulse pressure |
| url | http://www.cardiab.com/content/11/1/118 |
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