Bridgin connects the outer kinetochore to centromeric chromatin
The kinetochore is a multi-complex structure that helps attach chromosomes to spindle microtubules, ensuring accurate chromosome segregation during cell division. Kinetochores are thought to be evolutionarily conserved, but which components are conserved is unclear. Here, the authors report that som...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20161-9 |
| _version_ | 1819121074871205888 |
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| author | Shreyas Sridhar Tetsuya Hori Reiko Nakagawa Tatsuo Fukagawa Kaustuv Sanyal |
| author_facet | Shreyas Sridhar Tetsuya Hori Reiko Nakagawa Tatsuo Fukagawa Kaustuv Sanyal |
| author_sort | Shreyas Sridhar |
| collection | DOAJ |
| description | The kinetochore is a multi-complex structure that helps attach chromosomes to spindle microtubules, ensuring accurate chromosome segregation during cell division. Kinetochores are thought to be evolutionarily conserved, but which components are conserved is unclear. Here, the authors report that some members of the fungal phylum of Basidomycota lack many conventional kinetochore linker proteins. Instead, they possess a human Ki67-like protein that bridges the outer part of the kinetochore to centromere DNA, which may compensate for the loss of a conventional linker. |
| first_indexed | 2024-12-22T06:30:47Z |
| format | Article |
| id | doaj.art-95abe07f1bfc42eb91dc3f38ec5dc350 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T06:30:47Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-95abe07f1bfc42eb91dc3f38ec5dc3502022-12-21T18:35:43ZengNature PortfolioNature Communications2041-17232021-01-0112111910.1038/s41467-020-20161-9Bridgin connects the outer kinetochore to centromeric chromatinShreyas Sridhar0Tetsuya Hori1Reiko Nakagawa2Tatsuo Fukagawa3Kaustuv Sanyal4Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR)Laboratory of Chromosome Biology, Graduate School of Frontier Biosciences, Osaka UniversityLaboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory of Chromosome Biology, Graduate School of Frontier Biosciences, Osaka UniversityMolecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR)The kinetochore is a multi-complex structure that helps attach chromosomes to spindle microtubules, ensuring accurate chromosome segregation during cell division. Kinetochores are thought to be evolutionarily conserved, but which components are conserved is unclear. Here, the authors report that some members of the fungal phylum of Basidomycota lack many conventional kinetochore linker proteins. Instead, they possess a human Ki67-like protein that bridges the outer part of the kinetochore to centromere DNA, which may compensate for the loss of a conventional linker.https://doi.org/10.1038/s41467-020-20161-9 |
| spellingShingle | Shreyas Sridhar Tetsuya Hori Reiko Nakagawa Tatsuo Fukagawa Kaustuv Sanyal Bridgin connects the outer kinetochore to centromeric chromatin Nature Communications |
| title | Bridgin connects the outer kinetochore to centromeric chromatin |
| title_full | Bridgin connects the outer kinetochore to centromeric chromatin |
| title_fullStr | Bridgin connects the outer kinetochore to centromeric chromatin |
| title_full_unstemmed | Bridgin connects the outer kinetochore to centromeric chromatin |
| title_short | Bridgin connects the outer kinetochore to centromeric chromatin |
| title_sort | bridgin connects the outer kinetochore to centromeric chromatin |
| url | https://doi.org/10.1038/s41467-020-20161-9 |
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