The 3,4-Quinones of Estrone and Estradiol Are the Initiators of Cancer whereas Resveratrol and <i>N</i>-acetylcysteine Are the Preventers

The 3,4-Quinones of Estrone and Estradiol Are the Initiators of Cancer whereas Resveratrol and <i>N</i>-acetylcysteine Are the Preventers

This article reviews evidence suggesting that a common mechanism of initiation leads to the development of many prevalent types of cancer. Endogenous estrogens, in the form of catechol estrogen-3,4-quinones, play a central role in this pathway of cancer initiation. The catechol estrogen-3,4-quinones...

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Bibliographic Details
Main Authors: Ercole Cavalieri, Eleanor Rogan
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
cancer initiation
cancer prevention
estrogens
estrogen-DNA adducts
<i>N</i>-acetylcysteine
resveratrol
Online Access:https://www.mdpi.com/1422-0067/22/15/8238

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