The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats
Background/Objective: Hydrogen gas cavity is formed during in vivo degradation of magnesium implants. In many studies, the gas cavity is mostly punctured out subcutaneously. However, this procedure becomes inapplicable in certain internal surgeries; therefore, the effect of this gas cavity is worth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-04-01
|
| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X15000601 |
| _version_ | 1811268607430098944 |
|---|---|
| author | Deni Noviana Devi Paramitha Mokhamad Fakhrul Ulum Hendra Hermawan |
| author_facet | Deni Noviana Devi Paramitha Mokhamad Fakhrul Ulum Hendra Hermawan |
| author_sort | Deni Noviana |
| collection | DOAJ |
| description | Background/Objective: Hydrogen gas cavity is formed during in vivo degradation of magnesium implants. In many studies, the gas cavity is mostly punctured out subcutaneously. However, this procedure becomes inapplicable in certain internal surgeries; therefore, the effect of this gas cavity is worth further assessment.
Methods: In this study, we investigated the effect of hydrogen gas evolution on the mortality of rats and analysed the whole body capacity to relieve the gas. Porous pure-magnesium implants were implanted in the femoral bone defect of adult Sprague-Dawley rats up to 18 days, and their survival rate was calculated while the gas cavity size was measured, and its effect was analysed with support of radiographic and blood analysis.
Results: The gas cavity was rapidly formed surrounding the implantation site and obviously decreased the rats' survival rate. The gas was observed to swell the surrounding implantation site by filling the loose compartments and then dispersing subcutaneously to other areas.
Conclusion: The rat's whole body capacity was unable to tolerate the rapid and persistent hydrogen gas cavity formation as shown by high postimplantation mortality. |
| first_indexed | 2024-04-12T21:25:59Z |
| format | Article |
| id | doaj.art-95acd9b42cc44247b64cbc67ba3c942c |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-12T21:25:59Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-95acd9b42cc44247b64cbc67ba3c942c2022-12-22T03:16:11ZengElsevierJournal of Orthopaedic Translation2214-031X2016-04-015C91510.1016/j.jot.2015.08.003The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of ratsDeni Noviana0Devi Paramitha1Mokhamad Fakhrul Ulum2Hendra Hermawan3Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, IndonesiaFaculty of Veterinary Medicine, Bogor Agricultural University, Bogor, IndonesiaFaculty of Veterinary Medicine, Bogor Agricultural University, Bogor, IndonesiaDepartment of Mining, Metallurgical and Materials Engineering & CHU de Québec Research Centre, Laval University, Quebec City, CanadaBackground/Objective: Hydrogen gas cavity is formed during in vivo degradation of magnesium implants. In many studies, the gas cavity is mostly punctured out subcutaneously. However, this procedure becomes inapplicable in certain internal surgeries; therefore, the effect of this gas cavity is worth further assessment. Methods: In this study, we investigated the effect of hydrogen gas evolution on the mortality of rats and analysed the whole body capacity to relieve the gas. Porous pure-magnesium implants were implanted in the femoral bone defect of adult Sprague-Dawley rats up to 18 days, and their survival rate was calculated while the gas cavity size was measured, and its effect was analysed with support of radiographic and blood analysis. Results: The gas cavity was rapidly formed surrounding the implantation site and obviously decreased the rats' survival rate. The gas was observed to swell the surrounding implantation site by filling the loose compartments and then dispersing subcutaneously to other areas. Conclusion: The rat's whole body capacity was unable to tolerate the rapid and persistent hydrogen gas cavity formation as shown by high postimplantation mortality.http://www.sciencedirect.com/science/article/pii/S2214031X15000601biodegradable metalhydrogen evolutionmagnesiumratsurvival rate |
| spellingShingle | Deni Noviana Devi Paramitha Mokhamad Fakhrul Ulum Hendra Hermawan The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats Journal of Orthopaedic Translation biodegradable metal hydrogen evolution magnesium rat survival rate |
| title | The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| title_full | The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| title_fullStr | The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| title_full_unstemmed | The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| title_short | The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| title_sort | effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats |
| topic | biodegradable metal hydrogen evolution magnesium rat survival rate |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X15000601 |
| work_keys_str_mv | AT deninoviana theeffectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT deviparamitha theeffectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT mokhamadfakhrululum theeffectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT hendrahermawan theeffectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT deninoviana effectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT deviparamitha effectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT mokhamadfakhrululum effectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats AT hendrahermawan effectofhydrogengasevolutionofmagnesiumimplantonthepostimplantationmortalityofrats |