Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study
Søren Hauge Okholm,1 Dávid Nagy,1 Dóra Körmendiné Farkas,1 Cecilia Hvitfeldt Fuglsang,1 Frederikke Schønfeldt Troelsen,1 Victor W Henderson,1,2 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 2Departments of Epidemiolog...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Clinical Epidemiology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/non-traumatic-subdural-hematoma-and-cancer-a-cohort-study-peer-reviewed-fulltext-article-CLEP |
| _version_ | 1797830178697641984 |
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| author | Okholm SH Nagy D Körmendiné Farkas D Fuglsang CH Troelsen FS Henderson VW Sørensen HT |
| author_facet | Okholm SH Nagy D Körmendiné Farkas D Fuglsang CH Troelsen FS Henderson VW Sørensen HT |
| author_sort | Okholm SH |
| collection | DOAJ |
| description | Søren Hauge Okholm,1 Dávid Nagy,1 Dóra Körmendiné Farkas,1 Cecilia Hvitfeldt Fuglsang,1 Frederikke Schønfeldt Troelsen,1 Victor W Henderson,1,2 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 2Departments of Epidemiology & Population Health and of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USACorrespondence: Henrik Toft Sørensen, Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Olof Palmes Allé 43-45, Aarhus N, 8200, Denmark, Tel +45 87 16 82 15, Email hts@clin.au.dkIntroduction: Cancer may increase the risk of bleeding. However, whether subdural hematoma is a marker of occult cancer remains unknown. We examined the association between non-traumatic subdural hematoma and cancer risk in a cohort study.Materials and Methods: Using Danish nationwide health registries, we identified 2713 patients with non-traumatic subdural hematoma and no previous cancer diagnosis, who were hospitalized between April 1, 1996 and December 31, 2019. We computed age-, sex-, and calendar year-standardized incidence ratios (SIRs) as the ratio of the observed to expected number of patients with cancer by using national incidence rates as reference as a measure of relative risk.Results: We identified 77 cancer cases within the first year of follow-up and 272 cancer cases thereafter. The one-year risk of cancer was 2.8% (95% confidence interval: 2.2– 3.5), and the one-year SIR was 1.7 (95% confidence interval: 1.3– 2.1). During the subsequent years, the SIR was 1.0 (95% confidence interval: 0.9– 1.1). The relative risk was elevated for some hematological and liver cancers.Conclusion: The risk of a new cancer diagnosis was clearly increased in patients with non-traumatic subdural hematoma compared with the general population during the first year of follow-up. However, the absolute risk was low, thus limiting the clinical relevance of pursuing early cancer detection in these patients.Keywords: cancer, cohort study, epidemiology, non-traumatic subdural hematoma, population-based |
| first_indexed | 2024-04-09T13:33:06Z |
| format | Article |
| id | doaj.art-95ad0c3180a84a09bb7413f8fc3110dd |
| institution | Directory Open Access Journal |
| issn | 1179-1349 |
| language | English |
| last_indexed | 2024-04-09T13:33:06Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Epidemiology |
| spelling | doaj.art-95ad0c3180a84a09bb7413f8fc3110dd2023-05-09T18:57:55ZengDove Medical PressClinical Epidemiology1179-13492023-05-01Volume 1562963383582Non-Traumatic Subdural Hematoma and Cancer: A Cohort StudyOkholm SHNagy DKörmendiné Farkas DFuglsang CHTroelsen FSHenderson VWSørensen HTSøren Hauge Okholm,1 Dávid Nagy,1 Dóra Körmendiné Farkas,1 Cecilia Hvitfeldt Fuglsang,1 Frederikke Schønfeldt Troelsen,1 Victor W Henderson,1,2 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 2Departments of Epidemiology & Population Health and of Neurology & Neurological Sciences, Stanford University, Stanford, CA, USACorrespondence: Henrik Toft Sørensen, Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Olof Palmes Allé 43-45, Aarhus N, 8200, Denmark, Tel +45 87 16 82 15, Email hts@clin.au.dkIntroduction: Cancer may increase the risk of bleeding. However, whether subdural hematoma is a marker of occult cancer remains unknown. We examined the association between non-traumatic subdural hematoma and cancer risk in a cohort study.Materials and Methods: Using Danish nationwide health registries, we identified 2713 patients with non-traumatic subdural hematoma and no previous cancer diagnosis, who were hospitalized between April 1, 1996 and December 31, 2019. We computed age-, sex-, and calendar year-standardized incidence ratios (SIRs) as the ratio of the observed to expected number of patients with cancer by using national incidence rates as reference as a measure of relative risk.Results: We identified 77 cancer cases within the first year of follow-up and 272 cancer cases thereafter. The one-year risk of cancer was 2.8% (95% confidence interval: 2.2– 3.5), and the one-year SIR was 1.7 (95% confidence interval: 1.3– 2.1). During the subsequent years, the SIR was 1.0 (95% confidence interval: 0.9– 1.1). The relative risk was elevated for some hematological and liver cancers.Conclusion: The risk of a new cancer diagnosis was clearly increased in patients with non-traumatic subdural hematoma compared with the general population during the first year of follow-up. However, the absolute risk was low, thus limiting the clinical relevance of pursuing early cancer detection in these patients.Keywords: cancer, cohort study, epidemiology, non-traumatic subdural hematoma, population-basedhttps://www.dovepress.com/non-traumatic-subdural-hematoma-and-cancer-a-cohort-study-peer-reviewed-fulltext-article-CLEPcancercohort studyepidemiologynon-traumatic subdural hematomapopulation-based |
| spellingShingle | Okholm SH Nagy D Körmendiné Farkas D Fuglsang CH Troelsen FS Henderson VW Sørensen HT Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study Clinical Epidemiology cancer cohort study epidemiology non-traumatic subdural hematoma population-based |
| title | Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study |
| title_full | Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study |
| title_fullStr | Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study |
| title_full_unstemmed | Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study |
| title_short | Non-Traumatic Subdural Hematoma and Cancer: A Cohort Study |
| title_sort | non traumatic subdural hematoma and cancer a cohort study |
| topic | cancer cohort study epidemiology non-traumatic subdural hematoma population-based |
| url | https://www.dovepress.com/non-traumatic-subdural-hematoma-and-cancer-a-cohort-study-peer-reviewed-fulltext-article-CLEP |
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