Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations
The purpose of this paper is to investigate inter-tablet coating thickness variability based on different tablet shapes and filling levels. To achieve this goal, the Discrete Element Method (DEM) is applied, and efforts are made as following: For the first step, four different tablet shapes, referre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2018-01-01
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| Series: | MATEC Web of Conferences |
| Online Access: | https://doi.org/10.1051/matecconf/201823804008 |
| _version_ | 1818644502465740800 |
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| author | Zhang Qiushuang Wan Hui Jian Bin Hu Guoming |
| author_facet | Zhang Qiushuang Wan Hui Jian Bin Hu Guoming |
| author_sort | Zhang Qiushuang |
| collection | DOAJ |
| description | The purpose of this paper is to investigate inter-tablet coating thickness variability based on different tablet shapes and filling levels. To achieve this goal, the Discrete Element Method (DEM) is applied, and efforts are made as following: For the first step, four different tablet shapes, referred to as Sphere, SRC (Standard Round Concave), Oval and Triangular, are built by importing three (except Sphere) CAD templates to create one or more spherical surfaces. Furthermore, a spray zone in the coating pan is presented to monitor the change of the “coating mass”, by virtue of which we calculate the inter-tablet coating variability. And to complete this work, custom contact models and properties are created to describe coating. Then, three different filling levels are added to the simulation. Eventually, the compared results are analyzed between three diverse filling degrees among tablet particles with four discrepant shapes. |
| first_indexed | 2024-12-17T00:15:52Z |
| format | Article |
| id | doaj.art-95b12868c4e246d3a158bda45500af0d |
| institution | Directory Open Access Journal |
| issn | 2261-236X |
| language | English |
| last_indexed | 2024-12-17T00:15:52Z |
| publishDate | 2018-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | MATEC Web of Conferences |
| spelling | doaj.art-95b12868c4e246d3a158bda45500af0d2022-12-21T22:10:43ZengEDP SciencesMATEC Web of Conferences2261-236X2018-01-012380400810.1051/matecconf/201823804008matecconf_icnfm2018_04008Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM SimulationsZhang Qiushuang0Wan Hui1Jian Bin2Hu Guoming3School of Power and Mechanical Engineering, Wuhan UniversitySchool of Power and Mechanical Engineering, Wuhan UniversitySchool of Power and Mechanical Engineering, Wuhan UniversitySchool of Power and Mechanical Engineering, Wuhan UniversityThe purpose of this paper is to investigate inter-tablet coating thickness variability based on different tablet shapes and filling levels. To achieve this goal, the Discrete Element Method (DEM) is applied, and efforts are made as following: For the first step, four different tablet shapes, referred to as Sphere, SRC (Standard Round Concave), Oval and Triangular, are built by importing three (except Sphere) CAD templates to create one or more spherical surfaces. Furthermore, a spray zone in the coating pan is presented to monitor the change of the “coating mass”, by virtue of which we calculate the inter-tablet coating variability. And to complete this work, custom contact models and properties are created to describe coating. Then, three different filling levels are added to the simulation. Eventually, the compared results are analyzed between three diverse filling degrees among tablet particles with four discrepant shapes.https://doi.org/10.1051/matecconf/201823804008 |
| spellingShingle | Zhang Qiushuang Wan Hui Jian Bin Hu Guoming Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations MATEC Web of Conferences |
| title | Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations |
| title_full | Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations |
| title_fullStr | Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations |
| title_full_unstemmed | Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations |
| title_short | Comparisons of Inter-tablet Coating Variability under Different Tablet Shapes and Filling Levels by Using DEM Simulations |
| title_sort | comparisons of inter tablet coating variability under different tablet shapes and filling levels by using dem simulations |
| url | https://doi.org/10.1051/matecconf/201823804008 |
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