An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice

An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice

ABSTRACT New classes of antibiotics are needed to fight bacterial infections, and repurposing existing drugs as antibiotics may enable rapid deployment of new treatments. Screens for antibacterials have been traditionally performed in standard laboratory media, but bacterial pathogens experience ver...

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Bibliographic Details
Main Authors: Jack R. McLeod, Pamela A. Harvey, Corrella S. Detweiler
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
antibiotics
capecitabine
course-based undergraduate research experience (CURE)
5-fluorouracil (5-FU)
nucleoside analog
repurposing
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00275-21

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