Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid
Abstract Background To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid. Methods 5 polymorphic gene variants (rs1048943, rs4646421, rs2070676, rs3813867, rs1695) were studied in 399 people living in t...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10020-019-0117-y |
| _version_ | 1818219240386199552 |
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| author | Meruyert Massabayeva Nailya Chaizhunusova Nurlan Aukenov Tolkyn Bulegenov Bakytbek Apsalikov Aigerim Shapihanova Yersin Zhunussov |
| author_facet | Meruyert Massabayeva Nailya Chaizhunusova Nurlan Aukenov Tolkyn Bulegenov Bakytbek Apsalikov Aigerim Shapihanova Yersin Zhunussov |
| author_sort | Meruyert Massabayeva |
| collection | DOAJ |
| description | Abstract Background To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid. Methods 5 polymorphic gene variants (rs1048943, rs4646421, rs2070676, rs3813867, rs1695) were studied in 399 people living in the East Kazakhstan region in this research. 248 people of the 2nd - 3rd generation lived in the territory with radiation exposure in Abai, Borodulikha areas, and 151 people the comparison group lived in Kurchum district without radiation exposure comparable in sex and age with control group. Results The results show that there is a significant association of rs1048943 in exposed and unexposed groups (p < 0.003), and the absence of association of rs4646421, rs2070676, rs3813867, rs1695 in the studied groups. The mean value of thyroxine in carriers of the AG + GG genotype of rs4646421 is significantly lower than in AA genotype carriers (p = 0.04); no significant changes were found in genotypes’ distribution with thyroid-stimulating hormone and anti-thyroid peroxidase indicators. Significant changes were in levels of anti-thyroid peroxidase between exposed and unexposed groups (p = 0.007). The thyroxine - thyroid-stimulating hormone levels were not significantly different in exposed and unexposed groups (p > 0.3). Conclusions This study demonstrated the association of rs1048943 polymorphism with living in the radiation zone in the 2nd and 3rd generations for the first time. Thyroxine levels decrease was identified in the 2nd and 3rd generation residents of the exposed area, as well as a significant increase of anti-thyroid peroxidase occurs in individuals of the 2nd and 3rd generation living in areas with radiation exposure. |
| first_indexed | 2024-12-12T07:36:31Z |
| format | Article |
| id | doaj.art-95b7445570d74c8f9045cd38e9ef0b80 |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-12-12T07:36:31Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-95b7445570d74c8f9045cd38e9ef0b802022-12-22T00:32:54ZengBMCMolecular Medicine1076-15511528-36582019-11-012511510.1186/s10020-019-0117-yAssociation of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroidMeruyert Massabayeva0Nailya Chaizhunusova1Nurlan Aukenov2Tolkyn Bulegenov3Bakytbek Apsalikov4Aigerim Shapihanova5Yersin Zhunussov6Medical University SemeyMedical University SemeyDepartment of Health and Human Resources, Ministry of Health of the Republic of KazakhstanMedical University SemeyMedical University SemeyMedical University SemeyMedical University SemeyAbstract Background To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid. Methods 5 polymorphic gene variants (rs1048943, rs4646421, rs2070676, rs3813867, rs1695) were studied in 399 people living in the East Kazakhstan region in this research. 248 people of the 2nd - 3rd generation lived in the territory with radiation exposure in Abai, Borodulikha areas, and 151 people the comparison group lived in Kurchum district without radiation exposure comparable in sex and age with control group. Results The results show that there is a significant association of rs1048943 in exposed and unexposed groups (p < 0.003), and the absence of association of rs4646421, rs2070676, rs3813867, rs1695 in the studied groups. The mean value of thyroxine in carriers of the AG + GG genotype of rs4646421 is significantly lower than in AA genotype carriers (p = 0.04); no significant changes were found in genotypes’ distribution with thyroid-stimulating hormone and anti-thyroid peroxidase indicators. Significant changes were in levels of anti-thyroid peroxidase between exposed and unexposed groups (p = 0.007). The thyroxine - thyroid-stimulating hormone levels were not significantly different in exposed and unexposed groups (p > 0.3). Conclusions This study demonstrated the association of rs1048943 polymorphism with living in the radiation zone in the 2nd and 3rd generations for the first time. Thyroxine levels decrease was identified in the 2nd and 3rd generation residents of the exposed area, as well as a significant increase of anti-thyroid peroxidase occurs in individuals of the 2nd and 3rd generation living in areas with radiation exposure.http://link.springer.com/article/10.1186/s10020-019-0117-yRadiation riskSecond-third generationsCYP1А1CYP2Е1GSTP1 genes polymorphisms |
| spellingShingle | Meruyert Massabayeva Nailya Chaizhunusova Nurlan Aukenov Tolkyn Bulegenov Bakytbek Apsalikov Aigerim Shapihanova Yersin Zhunussov Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid Molecular Medicine Radiation risk Second-third generations CYP1А1 CYP2Е1 GSTP1 genes polymorphisms |
| title | Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid |
| title_full | Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid |
| title_fullStr | Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid |
| title_full_unstemmed | Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid |
| title_short | Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid |
| title_sort | association of radiation risk in the second and third generations with polymorphisms in the genes cyp1a1 cyp2e1 gstp1 and changes in the thyroid |
| topic | Radiation risk Second-third generations CYP1А1 CYP2Е1 GSTP1 genes polymorphisms |
| url | http://link.springer.com/article/10.1186/s10020-019-0117-y |
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