Invasive Fungal Infections Secondary to Traumatic Injury
Invasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic IFI in military and civilian populations. The...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-09-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971217301807 |
| _version_ | 1811314279840743424 |
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| author | Ryan Kronen Stephen Y. Liang Grant Bochicchio Kelly Bochicchio William G. Powderly Andrej Spec |
| author_facet | Ryan Kronen Stephen Y. Liang Grant Bochicchio Kelly Bochicchio William G. Powderly Andrej Spec |
| author_sort | Ryan Kronen |
| collection | DOAJ |
| description | Invasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic IFI in military and civilian populations. The epidemiology of post-traumatic IFI is poorly characterized, but incidence appears to be rising. Patients often suffer from severe injuries and require extensive medical interventions. Fungi belonging to the order Mucorales are responsible for most post-traumatic IFI in both civilian and military populations. Risk factors differ between these cohorts but include specific injury patterns and comorbidities. Diagnosis of post-traumatic IFI typically follows positive laboratory results in the appropriate clinical context. The gold standard of treatment is surgical debridement in addition to systemic antifungal therapy. Patients with post-traumatic IFI may be at greater risk of amputation, delays in wound healing, hospital complications, and death as compared to trauma patients who do not develop IFI. More research is needed to understand the factors surrounding the development and management of post-traumatic IFI to reduce the significant morbidity and mortality associated with this disease. |
| first_indexed | 2024-04-13T11:10:12Z |
| format | Article |
| id | doaj.art-95b7d7a1b95b4f87ac61108415f1a927 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-04-13T11:10:12Z |
| publishDate | 2017-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-95b7d7a1b95b4f87ac61108415f1a9272022-12-22T02:49:10ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-09-0162C10211110.1016/j.ijid.2017.07.002Invasive Fungal Infections Secondary to Traumatic InjuryRyan Kronen0Stephen Y. Liang1Grant Bochicchio2Kelly Bochicchio3William G. Powderly4Andrej Spec5Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USADivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USASection of Acute and Critical Care Surgery, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USASection of Acute and Critical Care Surgery, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USADivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USADivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO, USAInvasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic IFI in military and civilian populations. The epidemiology of post-traumatic IFI is poorly characterized, but incidence appears to be rising. Patients often suffer from severe injuries and require extensive medical interventions. Fungi belonging to the order Mucorales are responsible for most post-traumatic IFI in both civilian and military populations. Risk factors differ between these cohorts but include specific injury patterns and comorbidities. Diagnosis of post-traumatic IFI typically follows positive laboratory results in the appropriate clinical context. The gold standard of treatment is surgical debridement in addition to systemic antifungal therapy. Patients with post-traumatic IFI may be at greater risk of amputation, delays in wound healing, hospital complications, and death as compared to trauma patients who do not develop IFI. More research is needed to understand the factors surrounding the development and management of post-traumatic IFI to reduce the significant morbidity and mortality associated with this disease.http://www.sciencedirect.com/science/article/pii/S1201971217301807Invasive fungal infectiontraumamucormycosisadultcivilianmilitary |
| spellingShingle | Ryan Kronen Stephen Y. Liang Grant Bochicchio Kelly Bochicchio William G. Powderly Andrej Spec Invasive Fungal Infections Secondary to Traumatic Injury International Journal of Infectious Diseases Invasive fungal infection trauma mucormycosis adult civilian military |
| title | Invasive Fungal Infections Secondary to Traumatic Injury |
| title_full | Invasive Fungal Infections Secondary to Traumatic Injury |
| title_fullStr | Invasive Fungal Infections Secondary to Traumatic Injury |
| title_full_unstemmed | Invasive Fungal Infections Secondary to Traumatic Injury |
| title_short | Invasive Fungal Infections Secondary to Traumatic Injury |
| title_sort | invasive fungal infections secondary to traumatic injury |
| topic | Invasive fungal infection trauma mucormycosis adult civilian military |
| url | http://www.sciencedirect.com/science/article/pii/S1201971217301807 |
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