Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy
Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment program...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2015-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_3848_580542a1d4ce70993c0329fa2daa3b56.html |
| _version_ | 1818395066728710144 |
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| author | Liyana Hazwani Mohd Adnan Nor Hidayah Abu Bakar Nasir Mohamad |
| author_facet | Liyana Hazwani Mohd Adnan Nor Hidayah Abu Bakar Nasir Mohamad |
| author_sort | Liyana Hazwani Mohd Adnan |
| collection | DOAJ |
| description | Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights the potential use of prophetic medicines, Nigella sativa, as a supplement for opioid dependent receiving methadone. It focuses on the potential role of N. sativa and its major active compound, Thymoquinone (TQ) as a calcium channel blocking agent to reduce withdrawal syndrome and opioid dependency. |
| first_indexed | 2024-12-14T06:11:12Z |
| format | Article |
| id | doaj.art-95ba40f5a9e74e7580bf9b8295d7224b |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-14T06:11:12Z |
| publishDate | 2015-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-95ba40f5a9e74e7580bf9b8295d7224b2022-12-21T23:14:09ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742015-12-0117129269283848Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapyLiyana Hazwani Mohd Adnan0Nor Hidayah Abu Bakar1Nasir Mohamad2Faculty of Medicine and Health Sciences (FPSK), Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu,Terengganu, MalaysiaFaculty of Medicine and Health Sciences (FPSK), Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu,Terengganu, MalaysiaInnovation and Research; FPSK, UniSZA, 20400, Kuala Terengganu, Terengganu, MalaysiaMethadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights the potential use of prophetic medicines, Nigella sativa, as a supplement for opioid dependent receiving methadone. It focuses on the potential role of N. sativa and its major active compound, Thymoquinone (TQ) as a calcium channel blocking agent to reduce withdrawal syndrome and opioid dependency.http://ijbms.mums.ac.ir/pdf_3848_580542a1d4ce70993c0329fa2daa3b56.htmlCalcium channel blocker Methadone Nigella sativa Opioid dependence Thymoquinone |
| spellingShingle | Liyana Hazwani Mohd Adnan Nor Hidayah Abu Bakar Nasir Mohamad Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy Iranian Journal of Basic Medical Sciences Calcium channel blocker Methadone Nigella sativa Opioid dependence Thymoquinone |
| title | Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| title_full | Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| title_fullStr | Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| title_full_unstemmed | Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| title_short | Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| title_sort | opioid dependence and substitution therapy thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy |
| topic | Calcium channel blocker Methadone Nigella sativa Opioid dependence Thymoquinone |
| url | http://ijbms.mums.ac.ir/pdf_3848_580542a1d4ce70993c0329fa2daa3b56.html |
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