Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening
Background: Hydroxychloroquine (HCQS) is widely used to treat several rheumatic and skin diseases and can cause damage to the outer retina, known as HCQS retinopathy, and is common among long-term users of the drug with higher daily dose by weight. The goal of screening for retinopathy is to recogni...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-07-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/53352 |
| _version_ | 1827911099440168960 |
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| author | Jitendra Kumar Surabhi Gupta Rashmi Kumari |
| author_facet | Jitendra Kumar Surabhi Gupta Rashmi Kumari |
| author_sort | Jitendra Kumar |
| collection | DOAJ |
| description | Background: Hydroxychloroquine (HCQS) is widely used to treat several rheumatic and skin diseases and can cause damage to the outer retina, known as HCQS retinopathy, and is common among long-term users of the drug with higher daily dose by weight. The goal of screening for retinopathy is to recognize signs of toxicity at an early enough stage to prevent the loss of visual acuity.
Aims and Objectives: This study aimed to evaluate the diagnostic performance of a commercially available retinal thickness deviation map obtained by spectral-domain (SD) optical coherence tomography (OCT) for screening of HCQS retinopathy.
Materials and Methods: This study was a prospective comparative study between unaffected (patients who did not develop retina toxicity) and affected (who developed toxicity) of 50 patients of the age group of 14–60 years taking HCQS medication for several dermatological and rheumatologic disorders. The patients who fulfilled the inclusion criteria were screened for HCQS retinal toxicity using SD-OCT, standard automated perimetry, fundus autofluorescence, and comprehensive ophthalmic examinations.
Results: In this study, in group 2 patients, 60% were having parafoveal, 30% having perifoveal, and 10% having a mixed pattern (P<0.001) of HCQS retinopathy, and the mean deviation and pattern standard deviation increase as the severity of disease increases (P<0.005).
Conclusion: This study concluded that HCQS is a safer drug and can be used safely in these patients with proper HCQS retinal toxicity monitoring with an SD-OCT-generated retinal thickness deviation map and with regular follow-up to monitor reduced thickness in the parafoveal region. |
| first_indexed | 2024-03-13T01:59:31Z |
| format | Article |
| id | doaj.art-95bbfde8089c495993bd0b4f00cd951d |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-13T01:59:31Z |
| publishDate | 2023-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-95bbfde8089c495993bd0b4f00cd951d2023-07-02T05:14:50ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-07-01147132137https://doi.org/10.3126/ajms.v14i7.53352Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screeningJitendra Kumar 0https://orcid.org/0009-0009-3232-381XSurabhi Gupta 1https://orcid.org/0009-0006-0105-9444Rashmi Kumari 2https://orcid.org/0000-0001-9030-4099Professor and Head, Department of Ophthalmology, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Assistant Professor, Department of Ophthalmology, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, India Junior Resident, Department of Ophthalmology, Maharani Laxmi Bai Medical College, Jhansi, Uttar Pradesh, IndiaBackground: Hydroxychloroquine (HCQS) is widely used to treat several rheumatic and skin diseases and can cause damage to the outer retina, known as HCQS retinopathy, and is common among long-term users of the drug with higher daily dose by weight. The goal of screening for retinopathy is to recognize signs of toxicity at an early enough stage to prevent the loss of visual acuity. Aims and Objectives: This study aimed to evaluate the diagnostic performance of a commercially available retinal thickness deviation map obtained by spectral-domain (SD) optical coherence tomography (OCT) for screening of HCQS retinopathy. Materials and Methods: This study was a prospective comparative study between unaffected (patients who did not develop retina toxicity) and affected (who developed toxicity) of 50 patients of the age group of 14–60 years taking HCQS medication for several dermatological and rheumatologic disorders. The patients who fulfilled the inclusion criteria were screened for HCQS retinal toxicity using SD-OCT, standard automated perimetry, fundus autofluorescence, and comprehensive ophthalmic examinations. Results: In this study, in group 2 patients, 60% were having parafoveal, 30% having perifoveal, and 10% having a mixed pattern (P<0.001) of HCQS retinopathy, and the mean deviation and pattern standard deviation increase as the severity of disease increases (P<0.005). Conclusion: This study concluded that HCQS is a safer drug and can be used safely in these patients with proper HCQS retinal toxicity monitoring with an SD-OCT-generated retinal thickness deviation map and with regular follow-up to monitor reduced thickness in the parafoveal region.https://www.nepjol.info/index.php/AJMS/article/view/53352hydroxychloroquine; retinal toxicity; spectral-domain optical coherence tomography |
| spellingShingle | Jitendra Kumar Surabhi Gupta Rashmi Kumari Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening Asian Journal of Medical Sciences hydroxychloroquine; retinal toxicity; spectral-domain optical coherence tomography |
| title | Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| title_full | Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| title_fullStr | Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| title_full_unstemmed | Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| title_short | Use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| title_sort | use of optical coherence tomography retinal thickness deviation map for hydroxychloroquine retinopathy screening |
| topic | hydroxychloroquine; retinal toxicity; spectral-domain optical coherence tomography |
| url | https://www.nepjol.info/index.php/AJMS/article/view/53352 |
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