Inhibiting Lysyl Oxidases prevents pathologic cartilage calcification

Inhibiting Lysyl Oxidases prevents pathologic cartilage calcification

Lysyl oxidases (LOX(L)) are enzymes that catalyze the formation of cross-links in collagen and elastin fibers during physiologic calcification of bone. However, it remains unknown whether they may promote pathologic calcification of articular cartilage, an important hallmark of debilitating arthropa...

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Bibliographic Details
Main Authors: Ilaria Bernabei, Elodie Faure, Mario Romani, Julien Wegrzyn, Jürgen Brinckmann, Véronique Chobaz, Alexander So, Thomas Hugle, Nathalie Busso, Sonia Nasi
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cartilage
Mice
Pathologic calcification
Arthropathies
Lysyl oxidases
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223018735

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