Frequency and coexistence of recurrent chromosomal aberrations in multiple myeloma patients
Background: The genome of myeloma plasma cells is characterized by marked instability comprising both complex numeric and structural abnormalities. Recent data in the literature suggest that multiple myeloma (MM) is also associated with deletion of 1p, amplification of 1q, deletion of 6q and amplifi...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Slovenian Medical Association
2010-11-01
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Series: | Zdravniški Vestnik |
Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/317 |
Summary: | Background: The genome of myeloma plasma
cells is characterized by marked instability comprising
both complex numeric and structural
abnormalities. Recent data in the literature suggest
that multiple myeloma (MM) is also associated
with deletion of 1p, amplification of 1q,
deletion of 6q and amplification of 15q. These
chromosomal aberrations have an impact on
MM prognosis. We have looked for above mentioned
chromosomal abnormalities in 68 newly
diagnosed MM patients. Furthermore, our aim
was to establish whether certain chromosomal
abnormalities occur together with the others or
exclusively autonomously.
Methods: Chromosomal aberrations were detected
using commercially available FISH DNA
probes.
Results: Deletion of 1p, amplification of 1q, deletion
of 6q and amplification of 15q were present
in 10 %, 40 %, 10 % and 47 % of patients, respectively.
Our results confirm that amplification of 1q
and del(13)(q14.3) are highly associated. We also
detected an association between amplification of
1q and t(4;14)(p16.3;q32), and del(17)(p13.1). Additionally,
the association between amplification
of 15q and del(17)(p13.1), and del(6q) was statistically
confirmed.
Conclusions: Literature data confirm the prognostic
significance of newly tested chromosomal
abnormalities in MM patients. Since they are frequent
in our group of MM patients, the addition
of DNA-probes into MM FISH probe panel has a
substantial meaning for their detection . |
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ISSN: | 1318-0347 1581-0224 |