Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information.
A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 dail...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC5230763?pdf=render |
| _version_ | 1818882872688246784 |
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| author | Xiao Li Jessilyn Dunn Denis Salins Gao Zhou Wenyu Zhou Sophia Miryam Schüssler-Fiorenza Rose Dalia Perelman Elizabeth Colbert Ryan Runge Shannon Rego Ria Sonecha Somalee Datta Tracey McLaughlin Michael P Snyder |
| author_facet | Xiao Li Jessilyn Dunn Denis Salins Gao Zhou Wenyu Zhou Sophia Miryam Schüssler-Fiorenza Rose Dalia Perelman Elizabeth Colbert Ryan Runge Shannon Rego Ria Sonecha Somalee Datta Tracey McLaughlin Michael P Snyder |
| author_sort | Xiao Li |
| collection | DOAJ |
| description | A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography. |
| first_indexed | 2024-12-19T15:24:40Z |
| format | Article |
| id | doaj.art-95c438e951c541218f24826ef99d14cc |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T15:24:40Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-95c438e951c541218f24826ef99d14cc2022-12-21T20:15:55ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852017-01-01151e200140210.1371/journal.pbio.2001402Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information.Xiao LiJessilyn DunnDenis SalinsGao ZhouWenyu ZhouSophia Miryam Schüssler-Fiorenza RoseDalia PerelmanElizabeth ColbertRyan RungeShannon RegoRia SonechaSomalee DattaTracey McLaughlinMichael P SnyderA new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure). These events are associated with physiological macro-phenotypes such as fatigue, providing a strong association between reduced pressure/oxygen and fatigue on high-altitude flights. Importantly, we combined biosensor information with frequent medical measurements and made two important observations: First, wearable devices were useful in identification of early signs of Lyme disease and inflammatory responses; we used this information to develop a personalized, activity-based normalization framework to identify abnormal physiological signals from longitudinal data for facile disease detection. Second, wearables distinguish physiological differences between insulin-sensitive and -resistant individuals. Overall, these results indicate that portable biosensors provide useful information for monitoring personal activities and physiology and are likely to play an important role in managing health and enabling affordable health care access to groups traditionally limited by socioeconomic class or remote geography.http://europepmc.org/articles/PMC5230763?pdf=render |
| spellingShingle | Xiao Li Jessilyn Dunn Denis Salins Gao Zhou Wenyu Zhou Sophia Miryam Schüssler-Fiorenza Rose Dalia Perelman Elizabeth Colbert Ryan Runge Shannon Rego Ria Sonecha Somalee Datta Tracey McLaughlin Michael P Snyder Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. PLoS Biology |
| title | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. |
| title_full | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. |
| title_fullStr | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. |
| title_full_unstemmed | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. |
| title_short | Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information. |
| title_sort | digital health tracking physiomes and activity using wearable biosensors reveals useful health related information |
| url | http://europepmc.org/articles/PMC5230763?pdf=render |
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