Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation

Summary: Brain microenvironment plays an important role in neurodevelopment and pathology, where the extracellular matrix (ECM) and soluble factors modulate multiple cellular processes. Neural cell culture typically relies on heterologous matrices poorly resembling brain ECM. Here, we employed neuro...

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Main Authors: Daniel Simão, Marta M. Silva, Ana P. Terrasso, Francisca Arez, Marcos F.Q. Sousa, Narges Z. Mehrjardi, Tomo Šarić, Patrícia Gomes-Alves, Nuno Raimundo, Paula M. Alves, Catarina Brito
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118302832

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