Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease
Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orph...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/7/3763 |
| _version_ | 1797538756019879936 |
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| author | Chihiro Yamada |
| author_facet | Chihiro Yamada |
| author_sort | Chihiro Yamada |
| collection | DOAJ |
| description | Growth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it. |
| first_indexed | 2024-03-10T12:35:56Z |
| format | Article |
| id | doaj.art-95c8565562f94e4e8c8734b84ac48db7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:35:56Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-95c8565562f94e4e8c8734b84ac48db72023-11-21T14:15:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01227376310.3390/ijms22073763Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and DiseaseChihiro Yamada0Tsumura Kampo Research Laboratories, Tsumura & Co., Ibaraki 300-1192, JapanGrowth hormone secretagogue receptor 1a (GHS-R1a), which is one of the G protein-coupled receptors (GPCRs), is involved in various physiological actions such as energy consumption, growth hormone secretion promoting action, and cardiovascular protective action. The ligand was searched for as an orphan receptor for a while, but the ligand was found to be acylated ghrelin (ghrelin) discovered by Kangawa and Kojima et al. in 1999. Recently, it has also been reported that dysregulation of GHS-R1a mediates reduced feeding in various diseases. On the other hand, since the physiological effects of ghrelin have been studied exclusively in male mice, few studies have been conducted on gender differences in ghrelin reactivity. In this review, we describe (1) the characteristics of GHS-R1a, (2) the role of ghrelin in hypophagia due to stress or anticancer drugs, and (3) the gender differences in the physiological effects of GHS-R1a and the influence of stress on it.https://www.mdpi.com/1422-0067/22/7/3763growth hormone secretagogue receptor 1aGhrelingender differencefood intake |
| spellingShingle | Chihiro Yamada Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease International Journal of Molecular Sciences growth hormone secretagogue receptor 1a Ghrelin gender difference food intake |
| title | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
| title_full | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
| title_fullStr | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
| title_full_unstemmed | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
| title_short | Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease |
| title_sort | relationship between orexigenic peptide ghrelin signal gender difference and disease |
| topic | growth hormone secretagogue receptor 1a Ghrelin gender difference food intake |
| url | https://www.mdpi.com/1422-0067/22/7/3763 |
| work_keys_str_mv | AT chihiroyamada relationshipbetweenorexigenicpeptideghrelinsignalgenderdifferenceanddisease |