IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

Regulatory T (Treg) cells dampen an exaggerated immune response to viral infections in order to avoid immunopathology. Cytomegaloviruses (CMVs) are herpesviruses usually causing asymptomatic infection in immunocompetent hosts and induce strong cellular immunity which provides protection against CMV...

Full description

Bibliographic Details
Main Authors:	Branka Popovic, Mijo Golemac, Jürgen Podlech, Jelena Zeleznjak, Lidija Bilic-Zulle, Miodrag L Lukic, Luka Cicin-Sain, Matthias J Reddehase, Tim Sparwasser, Astrid Krmpotic, Stipan Jonjic
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-04-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1006345

Similar Items

CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach
by: Marko Šustić, et al.
Published: (2021-10-01)

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.
by: Niels A W Lemmermann, et al.
Published: (2015-02-01)

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
by: Adriana Tomić, et al.
Published: (2016-12-01)

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
by: Maja eArapovic, et al.
Published: (2016-04-01)

Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
by: Guillem Angulo, et al.
Published: (2021-01-01)

Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response
by: Stipan eJonjic
Published: (2011-12-01)

Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines
by: Lea Hiršl, et al.
Published: (2018-05-01)

Vaccine Vectors Harnessing the Power of Cytomegaloviruses
by: Mario Alberto Ynga-Durand, et al.
Published: (2019-10-01)

UL36 Rescues Apoptosis Inhibition and In vivo Replication of a Chimeric MCMV Lacking the M36 Gene
by: M. Zeeshan Chaudhry, et al.
Published: (2017-07-01)

Murine CMV-induced hearing loss is associated with inner ear inflammation and loss of spiral ganglia neurons.
by: Russell D Bradford, et al.
Published: (2015-04-01)

Cytomegalovirus Infection and Inflammation in Developing Brain
by: Fran Krstanović, et al.
Published: (2021-06-01)

Activation of innate and adaptive immunity by a recombinant human cytomegalovirus strain expressing an NKG2D ligand
by: Tomić, A, et al.
Published: (2016)

Memory CD8 T Cells Generated by Cytomegalovirus Vaccine Vector Expressing NKG2D Ligand Have Effector-Like Phenotype and Distinct Functional Features
by: Marko Šustić, et al.
Published: (2021-06-01)

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages.
by: Nadine Thiel, et al.
Published: (2016-12-01)

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.
by: Lars Dölken, et al.
Published: (2010-10-01)

Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
by: Ivana Strazic Geljic, et al.
Published: (2020-01-01)

Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus
by: Sanda Ravlić, et al.
Published: (2021-12-01)

Host-Adapted Gene Families Involved in Murine Cytomegalovirus Immune Evasion
by: Sara Becker, et al.
Published: (2022-01-01)

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.
by: Baca Chan, et al.
Published: (2017-05-01)

On academic plagiarism in Europe. An analytical approach based on four studies
by: Vanja Pupovac, et al.
Published: (2008-12-01)

On academic plagiarism in Europe. An analytical approach based on four studies
by: Vanja Pupovac, et al.
Published: (2020-01-01)

Učinci i sigurnosni profil dječjih cjepiva u svijetlu bioloških temelja imunološke reakcije
by: Luka Čičin-Šain
Published: (2023-01-01)

Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread
by: Rafaela Holtappels, et al.
Published: (2022-05-01)

Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
by: Jerome Moulden, et al.
Published: (2021-08-01)

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
by: Carmen Rožmanić, et al.
Published: (2023-10-01)

Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging.
by: Luka Cicin-Sain, et al.
Published: (2012-01-01)

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia.
by: Nico A Contreras, et al.
Published: (2019-06-01)

SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes
by: Mario Ynga-Durand, et al.
Published: (2022-06-01)

Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward.
by: Laura Olbrich, et al.
Published: (2021-12-01)

Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward
by: Laura Olbrich, et al.
Published: (2021-12-01)

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
by: Raghad Khaleafi, et al.
Published: (2023-09-01)

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.
by: Torsten Sacher, et al.
Published: (2011-11-01)

Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
by: Katarzyna M. Sitnik, et al.
Published: (2023-05-01)

Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation
by: Emin Gezinir, et al.
Published: (2020-06-01)

Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation
by: Matthias J. Reddehase
Published: (2016-08-01)

Innate lymphoid cells in neuroinflammation
by: Daria Kveštak, et al.
Published: (2024-02-01)

Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.
by: Simone Thomas, et al.
Published: (2015-07-01)

Decoding murine cytomegalovirus.
by: Manivel Lodha, et al.
Published: (2023-05-01)

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells.
by: Rafaela Holtappels, et al.
Published: (2023-11-01)

A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.
by: Yoshimi Tsuda, et al.
Published: (2011-08-01)