Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management
Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local salvage therapy, and salvage therapy has increa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/24/5883 |
| _version_ | 1797381679647555584 |
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| author | Eric S. Adams Sriram Deivasigamani Mahdi Mottaghi Jiaoti Huang Rajan T. Gupta Thomas J. Polascik |
| author_facet | Eric S. Adams Sriram Deivasigamani Mahdi Mottaghi Jiaoti Huang Rajan T. Gupta Thomas J. Polascik |
| author_sort | Eric S. Adams |
| collection | DOAJ |
| description | Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local salvage therapy, and salvage therapy has increased morbidity compared to primary treatments for prostate cancer. This review aims to provide an overview of the evaluation of patients with recurrent disease after radiation therapy and how it is continuing to evolve with increasing data on outcomes, as well as improving technologies and techniques. Our enhanced understanding of treatment outcomes and risk stratification has influenced the identification of patients who may benefit from local salvage treatment. Advances in imaging and biopsy techniques have enhanced the accuracy of locating the recurrence, which affects treatment decisions. Additionally, the growing interest in image-targeted ablative therapies that have less morbidity and complications than whole-gland therapies for suitable patients influences the evaluation process for those considering focal salvage therapy. Although significant changes have been made in the diagnostic evaluation of patients with recurrent disease after radiation therapy, it remains unclear whether these changes will ultimately improve patient outcomes. |
| first_indexed | 2024-03-08T20:54:54Z |
| format | Article |
| id | doaj.art-95ca9bf24b0a4eb8a49a2968104a2162 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T20:54:54Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-95ca9bf24b0a4eb8a49a2968104a21622023-12-22T13:59:09ZengMDPI AGCancers2072-66942023-12-011524588310.3390/cancers15245883Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary ManagementEric S. Adams0Sriram Deivasigamani1Mahdi Mottaghi2Jiaoti Huang3Rajan T. Gupta4Thomas J. Polascik5Department of Urology, Duke University Medical Center, Durham, NC 27710, USADepartment of Urology, Duke University Medical Center, Durham, NC 27710, USASection of Urology, Department of Surgery, Durham Veterans Affairs Medical Center, Durham, NC 27710, USADepartment of Pathology, Duke University Medical Center, Durham, NC 27710, USADepartment of Urology, Duke University Medical Center, Durham, NC 27710, USADepartment of Urology, Duke University Medical Center, Durham, NC 27710, USARecurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local salvage therapy, and salvage therapy has increased morbidity compared to primary treatments for prostate cancer. This review aims to provide an overview of the evaluation of patients with recurrent disease after radiation therapy and how it is continuing to evolve with increasing data on outcomes, as well as improving technologies and techniques. Our enhanced understanding of treatment outcomes and risk stratification has influenced the identification of patients who may benefit from local salvage treatment. Advances in imaging and biopsy techniques have enhanced the accuracy of locating the recurrence, which affects treatment decisions. Additionally, the growing interest in image-targeted ablative therapies that have less morbidity and complications than whole-gland therapies for suitable patients influences the evaluation process for those considering focal salvage therapy. Although significant changes have been made in the diagnostic evaluation of patients with recurrent disease after radiation therapy, it remains unclear whether these changes will ultimately improve patient outcomes.https://www.mdpi.com/2072-6694/15/24/5883prostate cancerlocalized recurrenceradiorecurrentradiotherapy failureradiation therapy failurepatient evaluation |
| spellingShingle | Eric S. Adams Sriram Deivasigamani Mahdi Mottaghi Jiaoti Huang Rajan T. Gupta Thomas J. Polascik Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management Cancers prostate cancer localized recurrence radiorecurrent radiotherapy failure radiation therapy failure patient evaluation |
| title | Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management |
| title_full | Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management |
| title_fullStr | Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management |
| title_full_unstemmed | Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management |
| title_short | Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management |
| title_sort | evaluation of recurrent disease after radiation therapy for patients considering local salvage therapy past vs contemporary management |
| topic | prostate cancer localized recurrence radiorecurrent radiotherapy failure radiation therapy failure patient evaluation |
| url | https://www.mdpi.com/2072-6694/15/24/5883 |
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