Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis
Abstract Background This paper aimed to analyze IncRNA SOX2-OT expression in patients with carotid atherosclerosis and to elucidate the predictive significance of SOX2-OT on carotid atherosclerosis. Methods The levels of SOX2-OT from 185 participants were tested. The relationship between CIMT levels...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02634-5 |
| _version_ | 1811252194097233920 |
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| author | Jianping Tao Yu Hu |
| author_facet | Jianping Tao Yu Hu |
| author_sort | Jianping Tao |
| collection | DOAJ |
| description | Abstract Background This paper aimed to analyze IncRNA SOX2-OT expression in patients with carotid atherosclerosis and to elucidate the predictive significance of SOX2-OT on carotid atherosclerosis. Methods The levels of SOX2-OT from 185 participants were tested. The relationship between CIMT levels and SOX2-OT expression was examined by Pearson analysis. The clinical value of SOX2-OT was investigated by the ROC curve, K–M curve, and COX regression analysis. The comparison of SOX2-OT expression between patients with good prognosis and poor prognosis was also performed. Results The expression of SOX2-OT was augmented in the patients with carotid atherosclerosis and was correlated with the level of CIMT. The high level of SOX2-OT might be a risk factor for carotid atherosclerosis. An enhancement of SOX2-OT expression was found in patients with poor prognosis. SOX2-OT might be an independent prognostic biomarker. Conclusions SOX2-OT was upregulated in patients with carotid atherosclerosis and might be a predictive indicator in the progression of carotid atherosclerosis. |
| first_indexed | 2024-04-12T16:31:13Z |
| format | Article |
| id | doaj.art-95cad7bdefb5406c9c68652a094f8e95 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T16:31:13Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-95cad7bdefb5406c9c68652a094f8e952022-12-22T03:25:09ZengBMCBMC Cardiovascular Disorders1471-22612022-05-012211610.1186/s12872-022-02634-5Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosisJianping Tao0Yu Hu1Department of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong UniversityDepartment of Cardiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong UniversityAbstract Background This paper aimed to analyze IncRNA SOX2-OT expression in patients with carotid atherosclerosis and to elucidate the predictive significance of SOX2-OT on carotid atherosclerosis. Methods The levels of SOX2-OT from 185 participants were tested. The relationship between CIMT levels and SOX2-OT expression was examined by Pearson analysis. The clinical value of SOX2-OT was investigated by the ROC curve, K–M curve, and COX regression analysis. The comparison of SOX2-OT expression between patients with good prognosis and poor prognosis was also performed. Results The expression of SOX2-OT was augmented in the patients with carotid atherosclerosis and was correlated with the level of CIMT. The high level of SOX2-OT might be a risk factor for carotid atherosclerosis. An enhancement of SOX2-OT expression was found in patients with poor prognosis. SOX2-OT might be an independent prognostic biomarker. Conclusions SOX2-OT was upregulated in patients with carotid atherosclerosis and might be a predictive indicator in the progression of carotid atherosclerosis.https://doi.org/10.1186/s12872-022-02634-5Carotid atherosclerosisSOX2-OTBiomarkerPrognosisDiagnosis |
| spellingShingle | Jianping Tao Yu Hu Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis BMC Cardiovascular Disorders Carotid atherosclerosis SOX2-OT Biomarker Prognosis Diagnosis |
| title | Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis |
| title_full | Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis |
| title_fullStr | Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis |
| title_full_unstemmed | Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis |
| title_short | Diagnostic and prognostic significance of lncRNA SOX2-OT in patients with carotid atherosclerosis |
| title_sort | diagnostic and prognostic significance of lncrna sox2 ot in patients with carotid atherosclerosis |
| topic | Carotid atherosclerosis SOX2-OT Biomarker Prognosis Diagnosis |
| url | https://doi.org/10.1186/s12872-022-02634-5 |
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