Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes
Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventio...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33656-4 |
| _version_ | 1811257208407588864 |
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| author | Xiaoxiao Yuan Ruirui Wang Bing Han ChengJun Sun Ruimin Chen Haiyan Wei Linqi Chen Hongwei Du Guimei Li Yu Yang Xiaojuan Chen Lanwei Cui Zhenran Xu Junfen Fu Jin Wu Wei Gu Zhihong Chen Xin Fang Hongxiu Yang Zhe Su Jing Wu Qiuyue Li Miaoying Zhang Yufeng Zhou Lei Zhang Guang Ji Feihong Luo |
| author_facet | Xiaoxiao Yuan Ruirui Wang Bing Han ChengJun Sun Ruimin Chen Haiyan Wei Linqi Chen Hongwei Du Guimei Li Yu Yang Xiaojuan Chen Lanwei Cui Zhenran Xu Junfen Fu Jin Wu Wei Gu Zhihong Chen Xin Fang Hongxiu Yang Zhe Su Jing Wu Qiuyue Li Miaoying Zhang Yufeng Zhou Lei Zhang Guang Ji Feihong Luo |
| author_sort | Xiaoxiao Yuan |
| collection | DOAJ |
| description | Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions. |
| first_indexed | 2024-04-12T17:52:55Z |
| format | Article |
| id | doaj.art-95cd9add604a4672870058794889679b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T17:52:55Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-95cd9add604a4672870058794889679b2022-12-22T03:22:26ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-33656-4Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetesXiaoxiao Yuan0Ruirui Wang1Bing Han2ChengJun Sun3Ruimin Chen4Haiyan Wei5Linqi Chen6Hongwei Du7Guimei Li8Yu Yang9Xiaojuan Chen10Lanwei Cui11Zhenran Xu12Junfen Fu13Jin Wu14Wei Gu15Zhihong Chen16Xin Fang17Hongxiu Yang18Zhe Su19Jing Wu20Qiuyue Li21Miaoying Zhang22Yufeng Zhou23Lei Zhang24Guang Ji25Feihong Luo26Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineInstitute of Pediatrics, Children’s Hospital of Fudan UniversityDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityFuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology and Inherited Metabolic, Children’s Hospital Affiliated to Zhengzhou UniversityChildren’s Hospital of Soochow UniversityThe First Hospital of Jilin UniversityDepartment of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityThe Affiliated Children’s Hospital of Nanchang UniversityDepartment of Endocrinology, Genetics and Metabolism, The Children’s Hospital of Shanxi ProvinceThe First Affiliated Hospital of Harbin Medical UniversityDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityDepartment of Endocrinology, Children’s Hospital, Zhejiang University School of MedicineDepartment of Pediatrics, West China Second University Hospital, Sichuan UniversityDepartment of Endocrinology, Children’s Hospital of Nanjing Medical UniversityDepartment of Neuroendocrinology Pediatrics, Affiliated Hospital of Qingdao UniversityFujian Medical University Union HospitalQingdao Women and Children’s HospitalShenzhen Children’s HospitalDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityInstitute of Pediatrics, Children’s Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan UniversityShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese MedicineInstitute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan UniversityHere, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.https://doi.org/10.1038/s41467-022-33656-4 |
| spellingShingle | Xiaoxiao Yuan Ruirui Wang Bing Han ChengJun Sun Ruimin Chen Haiyan Wei Linqi Chen Hongwei Du Guimei Li Yu Yang Xiaojuan Chen Lanwei Cui Zhenran Xu Junfen Fu Jin Wu Wei Gu Zhihong Chen Xin Fang Hongxiu Yang Zhe Su Jing Wu Qiuyue Li Miaoying Zhang Yufeng Zhou Lei Zhang Guang Ji Feihong Luo Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes Nature Communications |
| title | Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes |
| title_full | Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes |
| title_fullStr | Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes |
| title_full_unstemmed | Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes |
| title_short | Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes |
| title_sort | functional and metabolic alterations of gut microbiota in children with new onset type 1 diabetes |
| url | https://doi.org/10.1038/s41467-022-33656-4 |
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