Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study

Abstract Background Epidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between eGFR, MA with dementia and its subtypes: AD, VaD, a mixture of AD/VaD, a...

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Main Authors: Jessica Mira Gabin, Solfrid Romundstad, Ingvild Saltvedt, Jostein Holmen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Nephrology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12882-019-1425-8
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author Jessica Mira Gabin
Solfrid Romundstad
Ingvild Saltvedt
Jostein Holmen
author_facet Jessica Mira Gabin
Solfrid Romundstad
Ingvild Saltvedt
Jostein Holmen
author_sort Jessica Mira Gabin
collection DOAJ
description Abstract Background Epidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between eGFR, MA with dementia and its subtypes: AD, VaD, a mixture of AD/VaD, and other dementias. Methods Data from the second wave of the HUNT 2 Study (1995–1997) were linked with a dementia register known as the Health and Memory Study (HMS) collected during 1995–2011 in Nord-Trøndelag County, Norway. Dementia was ascertained using World Health Organization’s ICD-10 criteria into subtypes: AD,VaD, mixed AD/VaD, and other dementia. eGFR and its association with dementia was examined in 48,508 participants of the HUNT Study, of which 668 were diagnosed with all-cause dementia. Association between MA and dementia were studied in a subset of 7024 participants, and 214 were diagnosed with all-cause dementia. Cox regression models were conducted analyzing the association between dementia and MA using albumin creatine ratio (ACR). Cox regression models and Fine-Gray models were used to examine the association between dementia and eGFR. Results A positive association was found between increasing ACR and dementia. ACR in the fourth quartile (> 1.78 mg/mmol) with increased hazard ratio of VaD, 3.97 (1.12 to 14.07), compared with ACR in the first quartile (<.53 mg/mmol). There was no association between eGFR and dementia or its subgroups. Conclusions Our results strengthens the hypothesis that vascular mechanisms may affect both kidney and brain as an association between MA and dementia was found. However, eGFR was not significantly associated with dementia independent of diabetes mellitus or hypertension.
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spelling doaj.art-95cdf306ed9e4b65a1d686534f7e4ca62022-12-22T01:16:51ZengBMCBMC Nephrology1471-23692019-07-0120111010.1186/s12882-019-1425-8Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT studyJessica Mira Gabin0Solfrid Romundstad1Ingvild Saltvedt2Jostein Holmen3HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU)Department of Internal Medicine/Nephrology, Levanger Hospital, Health Trust Nord-TrøndelagDepartment of Neuromedicine and Movement science, Norwegian University of Science and TechnologyHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU)Abstract Background Epidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between eGFR, MA with dementia and its subtypes: AD, VaD, a mixture of AD/VaD, and other dementias. Methods Data from the second wave of the HUNT 2 Study (1995–1997) were linked with a dementia register known as the Health and Memory Study (HMS) collected during 1995–2011 in Nord-Trøndelag County, Norway. Dementia was ascertained using World Health Organization’s ICD-10 criteria into subtypes: AD,VaD, mixed AD/VaD, and other dementia. eGFR and its association with dementia was examined in 48,508 participants of the HUNT Study, of which 668 were diagnosed with all-cause dementia. Association between MA and dementia were studied in a subset of 7024 participants, and 214 were diagnosed with all-cause dementia. Cox regression models were conducted analyzing the association between dementia and MA using albumin creatine ratio (ACR). Cox regression models and Fine-Gray models were used to examine the association between dementia and eGFR. Results A positive association was found between increasing ACR and dementia. ACR in the fourth quartile (> 1.78 mg/mmol) with increased hazard ratio of VaD, 3.97 (1.12 to 14.07), compared with ACR in the first quartile (<.53 mg/mmol). There was no association between eGFR and dementia or its subgroups. Conclusions Our results strengthens the hypothesis that vascular mechanisms may affect both kidney and brain as an association between MA and dementia was found. However, eGFR was not significantly associated with dementia independent of diabetes mellitus or hypertension.http://link.springer.com/article/10.1186/s12882-019-1425-8EpidemiologyChronic kidney diseaseModerately increased albuminuriaDementiaAlzheimer diseaseVascular dementia
spellingShingle Jessica Mira Gabin
Solfrid Romundstad
Ingvild Saltvedt
Jostein Holmen
Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
BMC Nephrology
Epidemiology
Chronic kidney disease
Moderately increased albuminuria
Dementia
Alzheimer disease
Vascular dementia
title Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
title_full Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
title_fullStr Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
title_full_unstemmed Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
title_short Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study
title_sort moderately increased albuminuria chronic kidney disease and incident dementia the hunt study
topic Epidemiology
Chronic kidney disease
Moderately increased albuminuria
Dementia
Alzheimer disease
Vascular dementia
url http://link.springer.com/article/10.1186/s12882-019-1425-8
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AT ingvildsaltvedt moderatelyincreasedalbuminuriachronickidneydiseaseandincidentdementiathehuntstudy
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