Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum

Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum

Abstract Background Synapse loss is an early event that precedes neuronal death and symptom onset and is considered the best neuropathological correlate of cognitive decline in Alzheimer’s disease (AD). Vesicle-associated membrane protein 2 (VAMP-2) has emerged as a promising biomarker of AD-related...

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Bibliographic Details
Main Authors: Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
VAMP-2
SNAP-25
Neurogranin
Alzheimer’s disease
Synapse
Cerebrospinal fluid
Online Access:https://doi.org/10.1186/s13195-023-01336-0

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