Association between Silicone Breast Implants and Autoimmune Diseases
BACKGROUND AND AIM: Silicone breast implants have, for a long time, been considered as biologically inert and harmless. However the relationship between silicone breast implants and the risk of autoimmune diseases has generated intense medical interest. The aim of our review is to summarize the data...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
José de Mello Saúde
2017-09-01
|
| Series: | Gazeta Médica |
| Subjects: | |
| Online Access: | http://www.gazetamedica.pt/index.php/gazeta/article/view/48 |
| _version_ | 1818213019273920512 |
|---|---|
| author | Rute Carvalho Ana Filipa S. Lima Joana Barreira Vânia Guedes |
| author_facet | Rute Carvalho Ana Filipa S. Lima Joana Barreira Vânia Guedes |
| author_sort | Rute Carvalho |
| collection | DOAJ |
| description | BACKGROUND AND AIM: Silicone breast implants have, for a long time, been considered as biologically inert and harmless. However the relationship between silicone breast implants and the risk of autoimmune diseases has generated intense medical interest. The aim of our review is to summarize the data linking silicone breast implants and autoimmune diseases, including the most recent association with autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
METHODS: The clinical research included articles from the last 16 years using the MeSH terms “breast implants” and “autoimmune diseases” and also the following terms: “autoimmune/inflammatory syndrome induced by adjuvants” and “Shoenfeld’s syndrome”. The Oxford 2011 Levels of Evidence was used to assign a level-of-evidence.
Eligible articles included those who described a population of adult women (>17 years), which have breast implants versus women without implants. The clinical outcome measured was the development of an autoimmune disease.
RESULTS: Of the 268 obtained articles, five matched eligibility criteria (one meta-analysis, two systematic reviews and two cohort studies). Results show that although studies could not confirm an association between silicone breast implants and classical autoimmune diseases, a few studies demonstrated an association between implants
and undefined symptoms such as fatigue, arthralgia, myalgia and cognitive symptoms, which resembled a newly introduced syndrome, known as ASIA.
CONCLUSIONS: Evidence remains inconclusive about any association between silicone breast implants and classical autoimmune diseases. ASIA seems to be linked to previous exposition to an adjuvant such as silicone. However, we will need better evidence from large studies with accurate methodology to determine whether any true association exists between ASIA syndrome and silicone breast implants. |
| first_indexed | 2024-12-12T05:57:38Z |
| format | Article |
| id | doaj.art-95cebd4f332c47718eac15f7bfe8a77c |
| institution | Directory Open Access Journal |
| issn | 2183-8135 2184-0628 |
| language | English |
| last_indexed | 2024-12-12T05:57:38Z |
| publishDate | 2017-09-01 |
| publisher | José de Mello Saúde |
| record_format | Article |
| series | Gazeta Médica |
| spelling | doaj.art-95cebd4f332c47718eac15f7bfe8a77c2022-12-22T00:35:32ZengJosé de Mello SaúdeGazeta Médica2183-81352184-06282017-09-0134Association between Silicone Breast Implants and Autoimmune DiseasesRute Carvalho0Ana Filipa S. Lima1Joana Barreira2Vânia Guedes3USF Ermesinde, ACeS Maia/Valongo, Ermesinde, PortugalUSF Alto da Maia, ACeS Maia/Valongo, Maia, PortugalUSF Viver Mais, ACeS Maia/Valongo, Maia, PortugalUSF Faria Guimarães, ACeS Porto Oriental, Porto, PortugalBACKGROUND AND AIM: Silicone breast implants have, for a long time, been considered as biologically inert and harmless. However the relationship between silicone breast implants and the risk of autoimmune diseases has generated intense medical interest. The aim of our review is to summarize the data linking silicone breast implants and autoimmune diseases, including the most recent association with autoimmune/inflammatory syndrome induced by adjuvants (ASIA). METHODS: The clinical research included articles from the last 16 years using the MeSH terms “breast implants” and “autoimmune diseases” and also the following terms: “autoimmune/inflammatory syndrome induced by adjuvants” and “Shoenfeld’s syndrome”. The Oxford 2011 Levels of Evidence was used to assign a level-of-evidence. Eligible articles included those who described a population of adult women (>17 years), which have breast implants versus women without implants. The clinical outcome measured was the development of an autoimmune disease. RESULTS: Of the 268 obtained articles, five matched eligibility criteria (one meta-analysis, two systematic reviews and two cohort studies). Results show that although studies could not confirm an association between silicone breast implants and classical autoimmune diseases, a few studies demonstrated an association between implants and undefined symptoms such as fatigue, arthralgia, myalgia and cognitive symptoms, which resembled a newly introduced syndrome, known as ASIA. CONCLUSIONS: Evidence remains inconclusive about any association between silicone breast implants and classical autoimmune diseases. ASIA seems to be linked to previous exposition to an adjuvant such as silicone. However, we will need better evidence from large studies with accurate methodology to determine whether any true association exists between ASIA syndrome and silicone breast implants.http://www.gazetamedica.pt/index.php/gazeta/article/view/48Autoimmune DiseasesAutoimmunityBreast Implantation/adverse effectsSilicones/adverse effectsSilicone Gels/adverse effects |
| spellingShingle | Rute Carvalho Ana Filipa S. Lima Joana Barreira Vânia Guedes Association between Silicone Breast Implants and Autoimmune Diseases Gazeta Médica Autoimmune Diseases Autoimmunity Breast Implantation/adverse effects Silicones/adverse effects Silicone Gels/adverse effects |
| title | Association between Silicone Breast Implants and Autoimmune Diseases |
| title_full | Association between Silicone Breast Implants and Autoimmune Diseases |
| title_fullStr | Association between Silicone Breast Implants and Autoimmune Diseases |
| title_full_unstemmed | Association between Silicone Breast Implants and Autoimmune Diseases |
| title_short | Association between Silicone Breast Implants and Autoimmune Diseases |
| title_sort | association between silicone breast implants and autoimmune diseases |
| topic | Autoimmune Diseases Autoimmunity Breast Implantation/adverse effects Silicones/adverse effects Silicone Gels/adverse effects |
| url | http://www.gazetamedica.pt/index.php/gazeta/article/view/48 |
| work_keys_str_mv | AT rutecarvalho associationbetweensiliconebreastimplantsandautoimmunediseases AT anafilipaslima associationbetweensiliconebreastimplantsandautoimmunediseases AT joanabarreira associationbetweensiliconebreastimplantsandautoimmunediseases AT vaniaguedes associationbetweensiliconebreastimplantsandautoimmunediseases |